Recognition of cisplatin adducts by cellular proteins

被引：212

作者：

Kartalou, M ^{[1
]}

Essigmann, JM ^{[1
]}

机构：

[1] MIT, Div Bioengn & Environm Hlth, Dept Chem, Cambridge, MA 02139 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2001年 / 478卷 / 1-2期

关键词：

cisplatin; trans-DDP; DNA adducts; HMG box proteins; histone H1; TATA binding protein; Y-box binding protein; photolyase; XPE; XPA; RPA; ERCCI; mismatch reapir; 3-methyladenine DNA glycosylase; T4 endonuclease VII and Ku autoantigen;

D O I：

10.1016/S0027-5107(01)00142-7

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cisplatin is a widely used chemotherapeutic agent. It reacts with nucleophilic bases in DNA and forms 1,2-d(ApG), 1,2-d(GpG) and 1,3-d(GpTpG) intrastrand crosslinks, interstrand crosslinks and monofunctional adducts. The presence of these adducts in DNA is through to be responsible for the therapeutic efficacy of cisplatin. The exact signal transduction pathway that leads to cell cycle arrest and cell death following treatment with the drug is not known but cell death is believed to be mediated by the recognition of the adducts by cellular proteins. Here we describe the structural information available for cisplatin and related platinum adducts, the interactions of the adducts with cellular proteins and the implications of these interactions for cell survival. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 21

页数：21

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