T-cell receptor bias and immunity

被引：66

作者：

Gras, Stephanie ^{[2
]}

Kjer-Nielsen, Lars ^{[1
]}

Burrows, Scott R. ^{[3
]}

McCluskey, James ^{[1
]}

Rossjohn, Jamie ^{[2
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[2] Monash Univ, Protein Crytallog Unit, Dept Biochem & Mol Biol, Sch Biomed Sci, Clayton, Vic 3800, Australia

[3] Queensland Inst Med Res, Cellular Immunol Lab, Brisbane, Qld 4029, Australia

来源：

CURRENT OPINION IN IMMUNOLOGY | 2008年 / 20卷 / 01期

基金：

澳大利亚研究理事会; 英国医学研究理事会;

关键词：

D O I：

10.1016/j.coi.2007.12.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite the potentially vast T-cell repertoire, biased alpha beta T-cell receptor (TCR) usage has emerged as a common theme in immunity. Examples of TCR bias are observed in classical polymorphic major histocompatibility complex (MHC)-restricted immune responses as well as in T-cell responses to non-classical,monomorphic Ag-presenting molecules, such as CD1d. Recent data have implicated the structural landscape of these antigen-presenting molecules as one of the drivers of TCR bias. Here we review recent advances in the field, focussing on structural data pertaining to biased TCR usage, and discuss the implications for T-cell repertoire selection, MHC restriction and therapeutic development.

引用

页码：119 / 125

页数：7

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