Isolation and synthesis of a new clerodane from Echinodorus grandiflorus

被引：36

作者：

Costa, M

Tanaka, CMA

Imamura, PM

Marsaioli, AJ

机构：

[1] Univ Estadual Campinas, Inst Quim, BR-13081970 Campinas, SP, Brazil

[2] UEM, Dept Quim, Maringa, Parana, Brazil

来源：

PHYTOCHEMISTRY | 1999年 / 50卷 / 01期

关键词：

Echinodorus grandiflorus; Alismataceae; clerodane; absolute configuration; hemisynthesis of a clerodane;

D O I：

10.1016/S0031-9422(98)00464-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new clerodane derivative, (-)-16-hydroxycleroda-3,13-dien-16,15-olide-18-oic acid, (4a alpha,6 alpha,8a alpha) 1-carboxy-5(S)-[2(2,5-dihydro-5-hydroxy-2-oxo-4-furanyl)ethyl-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-naphthalene was isolated as a minor component of the polar fractions of the leaves of E. grandiflorus. The structure was determined by spectroscopy (IR, MS, 1D and 2D H-1 and C-13 NMR). The absolute configuration was determined by a hemisynthesis using (+)-hardwickiic acid methyl ester, from commercial copaiba oil, as starting material. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：117 / 122

页数：6

共 10 条

[1]

ARAUJO AR, 1991, THESIS UNICAMP

[2] ISOLATION AND INSECTICIDAL ACTIVITY OF (-)-HARDWICKIIC ACID FROM CROTON-AROMATICUS [J].