Biomarker detection based on nanowire biosensors has attracted a significant amount of research effort in recent years. However, only very limited research work has been directed toward biomarker detection directly from physiological fluids mainly because of challenges caused by the complexity of media. This limitation significantly reduces the practical impact generated by the aforementioned nanobiosensors. In this study, we demonstrate an In2O3 nanowire-based biosensing system that is capable of performing rapid, label-free, electrical detection of cancer biomarkers directly from human whole blood collected by a finger prick. Passivating the nanowire surface successfully blocked the signal induced by nonspecific binding when performing active measurement in whole blood. Passivated devices showed markedly smaller signals induced by nonspecific binding of proteins and other biomaterials in serum and higher sensitivity to target biomarkers than bare devices. The detection limit of passivated sensors for biomarkers in whole blood was similar to the detection limit for the same analyte in purified buffer solutions at the same ionic strength, suggesting minimal decrease In device performance in the complex media. We then demonstrated detection of multiple cancer biomarkers with high reliability at clinically meaningful concentrations from whole blood collected by a finger pick using this sensing system.
机构:
Rush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Rush Univ, Dept Pathol, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Borgia, Jeffrey A.
;
Basu, Sanjib
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Biostat, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Basu, Sanjib
;
Faber, L. Penfield
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Thorac Surg, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Faber, L. Penfield
;
Kim, Anthony W.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Thorac Surg, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Kim, Anthony W.
;
Coon, John S.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Pathol, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Coon, John S.
;
Kaiser-Walters, Kelly A.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Pathol, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Kaiser-Walters, Kelly A.
;
Fhied, Cristina
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Fhied, Cristina
;
Thomas, Sherene
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Thomas, Sherene
;
Rouhi, Omid
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Rush Univ, Dept Med Oncol, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Rouhi, Omid
;
Warren, William H.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Thorac Surg, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Warren, William H.
;
Bonomi, Philip
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Med Oncol, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Bonomi, Philip
;
Liptay, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Thorac Surg, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
机构:
Rush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Rush Univ, Dept Pathol, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Borgia, Jeffrey A.
;
Basu, Sanjib
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Biostat, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Basu, Sanjib
;
Faber, L. Penfield
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Thorac Surg, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Faber, L. Penfield
;
Kim, Anthony W.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Thorac Surg, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Kim, Anthony W.
;
Coon, John S.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Pathol, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Coon, John S.
;
Kaiser-Walters, Kelly A.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Pathol, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Kaiser-Walters, Kelly A.
;
Fhied, Cristina
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Fhied, Cristina
;
Thomas, Sherene
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Thomas, Sherene
;
Rouhi, Omid
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Rush Univ, Dept Med Oncol, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Rouhi, Omid
;
Warren, William H.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Thorac Surg, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Warren, William H.
;
Bonomi, Philip
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Med Oncol, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA
Bonomi, Philip
;
Liptay, Michael J.
论文数: 0引用数: 0
h-index: 0
机构:
Rush Univ, Dept Thorac Surg, Med Ctr, Chicago, IL 60612 USARush Univ, Dept Biochem, Med Ctr, Chicago, IL 60612 USA