The role of high-density lipoproteins in oxidation and inflammation

被引：121

作者：

Van Lenten, BJ ^{[1
]}

Navab, M

Shih, D

Fogelman, AM

Lusis, AJ

机构：

[1] Univ Calif Los Angeles, Sch Med, Atherosclerosis Res Unit, Div Cardiol,Dept Med 47 123 CHS, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Sch Med, Dept Microbiol Immunol & Mol Genet, Dept Human Genet, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Sch Med, Inst Mol Biol, Los Angeles, CA 90095 USA

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2001年 / 11卷 / 3-4期

关键词：

D O I：

10.1016/S1050-1738(01)00095-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

High-density lipoproteins (HDL) in the basal state are anti-inflammatory, capable of destroying oxidized lipids that generate an inflammatory response. However, HDL during acute inflammation are altered and become pro-inflammatory. This "chameleon-like" nature of HDL is considered to be due to the complex composition of HDL. The data reviewed here demonstrate the key role of HDL in modulating inflammation and its implications for atherogenesis. (C) 2001, Elsevier Science Inc.

引用

页码：155 / 161

页数：7

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