MHC class II signaling in antigen-presenting cells

被引：121

作者：

Al-Daccak, R

Mooney, N

Charron, D

机构：

[1] Inst Univ Hematol, AP HP, Hop St Louis, Lab Immunol & Histocompatibilite, F-75475 Paris, France

[2] Inst Natl Sante & Rech Med, U396, Inst Rech Biomed Cordeliers, IFR58,Lab Immunogenet Humaine, F-75006 Paris, France

来源：

CURRENT OPINION IN IMMUNOLOGY | 2004年 / 16卷 / 01期

关键词：

D O I：

10.1016/j.coi.2003.11.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The MHC class II molecules have been recognized as signaling receptors for more than a decade, and recent work has revealed the importance of their signaling for the immune response. Today, we know that the function of MHC class II molecules on antigen-presenting cells (APCs) is not limited to their role as antigen-presenting structures; they are flexible receptors that, by triggering a variety of signaling pathways, can regulate APC activities from proliferation and maturation to apoptosis. Recent advances have provided insights into how these molecules might accommodate such regulation.

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页码：108 / 113

页数：6

相关论文

共 63 条

[1] Cutting edge: The dendritic cell cytoskeleton is critical for the formation of the immunological synapse [J].

Al-Alwan, MM ;

Rowden, G ;

Lee, TDG ;

West, KA .

JOURNAL OF IMMUNOLOGY, 2001, 166 (03) :1452-1456

[2] Concentration of MHC class II molecules in lipid rafts facilitates antigen presentation [J].

Anderson, HA ;

Hiltbold, EM ;

Roche, PA .

NATURE IMMUNOLOGY, 2000, 1 (02) :156-162

[3] DISTINCT STRUCTURAL COMPARTMENTALIZATION OF THE SIGNAL-TRANSDUCING FUNCTIONS OF MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II (IA) MOLECULES [J].

ANDRE, P ;

CAMBIER, JC ;

WADE, TK ;

RAETZ, T ;

WADE, WF .

JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (02) :763-768

[4] MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223) [J].

Andreae, S ;

Buisson, S ;

Triebel, F .

BLOOD, 2003, 102 (06) :2130-2137

[5] Maturation and activation of dendritic cells induced by lymphocyte activation gene-3 (CD223) [J].

Andreae, S ;

Piras, F ;

Burdin, N ;

Triebel, F .

JOURNAL OF IMMUNOLOGY, 2002, 168 (08) :3874-3880

[6] Intracytoplasmic domains of MHC class II molecules are essential for lipid-raft-dependent signaling [J].

Bécart, S ;

Setterblad, N ;

Ostrand-Rosenberg, S ;

Ono, SJ ;

Charron, D ;

Mooney, N .

JOURNAL OF CELL SCIENCE, 2003, 116 (12) :2565-2575

[7] HLA-DR-mediated apoptosis susceptibility discriminates differentiation stages of dendritic/monocytic APC [J].

Bertho, N ;

Drénou, B ;

Laupeze, B ;

Le Berre, C ;

Amiot, L ;

Grosset, JM ;

Fardel, O ;

Charron, D ;

Mooney, N ;

Fauchet, R .

JOURNAL OF IMMUNOLOGY, 2000, 164 (05) :2379-2385

[8] MHC class II-mediated apoptosis of mature dendritic cells proceeds by activation of the protein kinase C-δ isoenzyme [J].

Bertho, N ;

Blancheteau, VM ;

Setterblad, N ;

Laupeze, B ;

Lord, JM ;

Drénou, B ;

Amiot, L ;

Charron, DJ ;

Fauchet, R ;

Mooney, N .

INTERNATIONAL IMMUNOLOGY, 2002, 14 (08) :935-942

[9] HAPLOTYPE-SPECIFIC DIFFERENCES IN SIGNALING BY TRANSFECTED CLASS-II MOLECULES TO A LY-1+ B-CELL CLONE [J].

BISHOP, GA ;

FRELINGER, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) :5933-5937

[10] Regulation of MHC class II signal transduction by the B cell coreceptors CD19 and CD22 [J].

Bobbitt, KR ;

Justement, LB .

JOURNAL OF IMMUNOLOGY, 2000, 165 (10) :5588-5596

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