Increase of neuron-specific enolase in patients with Creutzfeldt-Jakob disease

被引：37

作者：

Kropp, S

Zerr, I

Schulz-Schaeffer, WJ

Riedemann, C

Bodemer, M

Laske, C

Kretzschmar, HA

Poser, S

机构：

[1] Univ Gottingen, Neurol Klin & Poliklin, D-37075 Gottingen, Germany

[2] Univ Gottingen, Abt Neuropathol, D-37075 Gottingen, Germany

来源：

NEUROSCIENCE LETTERS | 1999年 / 261卷 / 1-2期

关键词：

Creutzfeldt-Jakob disease; neuron-specific enolase; cerebrospinal fluid; disease progression;

D O I：

10.1016/S0304-3940(98)00992-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative human disorder with an incidence of one case per 1 000 000 per year; Recently new diagnostic tests such as neuron-specific enolase (NSE), S-100, tau-protein and protein 14-3-3 have been established as markers in prion diseases. NSE is elevated in case of rapid nerve cell loss so quantitative measurement of NSE in cerebrospinal fluid (CSF) might correlate with the disease progression. To further evaluate this hypothesis we analysed longitudinal CSF samples from -16 CJD patients. The first spinal tap was taken two weeks after the first clinical signs of a neurodegenerative disorder. This showed an elevation of NSE which continued during the course of the disease. Longitudinal examination of neuron-specific enolase in cerebrospinal fluid therefore may be useful for differentiation between CJD and other dementias. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：124 / 126

页数：3

共 15 条

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