Hedgehog signaling: Costal-2 bridges the transiduction gap

被引：28

作者：

Kalderon, D ^{[1
]}

机构：

[1] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 02期

关键词：

D O I：

10.1016/j.cub.2003.12.047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Drosophila genetics has provided the Hedgehog signaling pathway with roughly ordered components, but few mechanistic connections. Several studies now show that the kinesin-related protein Costal-2 provides a physical link between the transmembrane transducer Smoothened and the transcriptional effector Cubitus interruptus.

引用

收藏

页码：R67 / R69

页数：3

相关论文

共 20 条

[1] Frizzled receptor dimerization is sufficient to activate the Wnt/β-catenin pathway [J].

Carron, C ;

Pascal, A ;

Djiane, A ;

Boucaut, JC ;

Shi, DL ;

Umbhauer, M .

JOURNAL OF CELL SCIENCE, 2003, 116 (12) :2541-2550

[2] Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains [J].

Dann, CE ;

Hsieh, JC ;

Rattner, A ;

Sharma, D ;

Nathans, J ;

Leahy, DJ .

NATURE, 2001, 412 (6842) :86-90

[3] Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened [J].

Denef, N ;

Neubüser, D ;

Perez, L ;

Cohen, SM .

CELL, 2000, 102 (04) :521-531

[4] Smoothened translates Hedgehog levels into distinct responses [J].

Hooper, JE .

DEVELOPMENT, 2003, 130 (17) :3951-3963

[5] Sonic hedgehog induces the segregation of patched and smoothened in endosomes [J].

Incardona, JP ;

Gruenberg, J ;

Roelink, H .

CURRENT BIOLOGY, 2002, 12 (12) :983-995

[6] Hedgehog signaling in animal development: paradigms and principles [J].

Ingham, PW ;

McMahon, AP .

GENES & DEVELOPMENT, 2001, 15 (23) :3059-3087

[7] Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail [J].

Jia, JH ;

Tong, C ;

Jiang, J .

GENES & DEVELOPMENT, 2003, 17 (21) :2709-2720

[8] Similarities between the Hedgehog and Wnt signaling pathways [J].

Kalderon, D .

TRENDS IN CELL BIOLOGY, 2002, 12 (11) :523-531

[9] Hedgehog signal transduction via smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2 [J].

Lum, L ;

Zhang, C ;

Oh, S ;

Mann, RK ;

von Kessler, DP ;

Taipale, J ;

Weis-Garcia, F ;

Gong, RY ;

Wang, BL ;

Beachy, PA .

MOLECULAR CELL, 2003, 12 (05) :1261-1274

[10] Developmental roles and clinical significance of hedgehog signaling [J].

McMahon, AP ;

Ingham, PW ;

Tabin, CJ .

CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, VOL 53, 2003, 53 :1-114