Serum albumin is a useful prognostic indicator and adds important information to NT-proBNP in a Chinese cohort of heart failure

被引:44
作者
Su, Wenting
An, Tao
Zhou, Qiong
Huang, Yan
Zhang, Jian [1 ]
Zhang, Yuhui
Wei, Bingqi
Sun, Xiaolu
Zou, Changhong
Lou, Kejia
机构
[1] Fuwai Hosp, Dept Emergency Ctr, Beijing, Peoples R China
关键词
Heart failure; Serum albumin; Prognosis; NT-proBNP; LIVER-FUNCTION; RISK; MORTALITY; ABNORMALITIES; PRESSURE;
D O I
10.1016/j.clinbiochem.2012.02.010
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
100118 [医学信息学]; 100208 [临床检验诊断学];
摘要
Objective: To evaluate the effect of serum albumin on prognosis and the power of albumin adding information to NT-proBNP in a Chinese cohort of heart failure. Design and methods: 385 consecutive patients (male vs. female: 292 vs. 93; mean age: 54.89 +/- 14.41 years; NYHA classes II-V) admitted for heart failure exacerbation with LVEF <= 45% were enrolled, and biochemical data was measured at baseline. The endpoint was defined as cardiac death or rehospitalization for aggravated heart failure. Follow-up period was 25 +/- 7 months. Results: Multivariate analysis in a Cox proportional hazard model revealed serum albumin was an independent predictor for adverse prognosis (HR 0.96,CI 0.94-0.99, P = 0.02), and the patients with higher NT-proBNP and lower albumin than median had the highest risk for cardiac events (HR 2.89, CI 1.90-4.40, P < 0.01). Conclusion: Serum albumin is a significant prognosis indicator for heart failure and it adds important information to NT-proBNP. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
引用
收藏
页码:561 / 565
页数:5
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