Homogeneity of asthma genome scan results

被引：1

作者：

Babron, MC ^{[1
]}

Selinger-Leneman, H ^{[1
]}

Dizier, MH ^{[1
]}

Clerget-Darpoux, F ^{[1
]}

机构：

[1] INSRM U535, F-94276 Le Kremlin Bicetre, France

来源：

GENETIC EPIDEMIOLOGY | 2001年 / 21卷

关键词：

genome scan; homogeneity; linkage analysis; MLS; power;

D O I：

10.1002/gepi.2001.21.s1.s44

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Three different samples of families with asthmatic patients, the German data set and the CSGA data set subdivided into Caucasian and African American groups, were analyzed using the maximum lod score statistic. Although different scores were obtained in each sample, the Wald's likelihood homogeneity test did not reveal any significant genetic heterogeneity. This may be due to the very large variance of the model-free linkage statistics. (C) 2001 Wiley-Liss, Inc.

引用

页码：S44 / S48

页数：5

共 11 条

[1]

Clerget-Darpoux F, 2000, INT STAT REV, V68, P45

[2]

HOLMANS P, 1993, AM J HUM GENET, V52, P362

[3]

KRUGLYAK L, 1995, AM J HUM GENET, V57, P439

[4]

Marsh DG, 1997, NAT GENET, V15, P389

[5]

RISCH N, 1990, AM J HUM GENET, V46, P242

[6] AFFECTED SIB PAIR IBD DISTRIBUTION FOR HLA-LINKED DISEASE SUSCEPTIBILITY GENES [J].

SUAREZ, BK .

TISSUE ANTIGENS, 1978, 12 (02) :87-93

[7] Tests of statistical hypotheses concerning several parameters when the number of observations is large [J].

Wald, Abraham .

TRANSACTIONS OF THE AMERICAN MATHEMATICAL SOCIETY, 1943, 54 (1-3) :426-482

[8] A genome-wide search for linkage to asthma [J].

Wjst, M ;

Fischer, G ;

Immervoll, T ;

Jung, M ;

Saar, K ;

Rueschendorf, F ;

Reis, A ;

Ulbrecht, M ;

Gomolka, M ;

Weiss, EH ;

Jaeger, L ;

Nickel, R ;

Richter, K ;

Kjellman, NIM ;

Griese, M ;

von Berg, A ;

Gappa, M ;

Riedel, F ;

Boehle, M ;

van Koningsbruggen, S ;

Schoberth, P ;

Szczepanski, R ;

Dorsch, W ;

Silbermann, M ;

Loesgen, S ;

Scholz, M ;

Bickeböller, H ;

Wichmann, HE .

GENOMICS, 1999, 58 (01) :1-8

[9] COLLABORATIVE STUDY ON THE GENETICS OF ASTHMA IN GERMANY [J].

WJST, M ;

WICHMANN, HE .

CLINICAL AND EXPERIMENTAL ALLERGY, 1995, 25 :23-25

[10]

GENETIC LOCATION DAT

← 1 2 →