The RITS complex - A direct link between small RNA and heterochromatin

被引:31
作者
Ekwall, K [1 ]
机构
[1] Karolinska Inst, Dept Biosci, S-14189 Huddinge, Sweden
[2] Univ Coll Sodertorn, Dept Nat Sci, S-14189 Huddinge, Sweden
关键词
D O I
10.1016/S1097-2765(04)00057-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In a recent report, Moazed, Grewal, and colleagues (Verdel et al., 2004) characterize the RITS (RNA-induced initiation of transcriptional silencing) protein complex in fission yeast. They provide a sought-for link between the small RNA produced by the RNA interference machinery and heterochromatin components, suggesting a mechanism for how heterochromatin formation can be targeted in trans to specific chromosomal regions.
引用
收藏
页码:304 / 305
页数:2
相关论文
共 13 条
  • [1] Role for a bidentate ribonuclease in the initiation step of RNA interference
    Bernstein, E
    Caudy, AA
    Hammond, SM
    Hannon, GJ
    [J]. NATURE, 2001, 409 (6818) : 363 - 366
  • [2] Ekwall K, 1999, GENETICS, V153, P1153
  • [3] Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    Fire, A
    Xu, SQ
    Montgomery, MK
    Kostas, SA
    Driver, SE
    Mello, CC
    [J]. NATURE, 1998, 391 (6669) : 806 - 811
  • [4] Analysis of a piwi-related gene implicates small RNAs in genome rearrangement in tetrahymena
    Mochizuki, K
    Fine, NA
    Fujisawa, T
    Gorovsky, MA
    [J]. CELL, 2002, 110 (06) : 689 - 699
  • [5] RNAi related mechanisms affect both transcriptional and posttranscriptional transgene silencing in Drosophila
    Pal-Bhadra, M
    Bhadra, U
    Birchler, JA
    [J]. MOLECULAR CELL, 2002, 9 (02) : 315 - 327
  • [6] cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site
    Partridge, JF
    Scott, KSC
    Bannister, AJ
    Kouzarides, T
    Allshire, RC
    [J]. CURRENT BIOLOGY, 2002, 12 (19) : 1652 - 1660
  • [7] Dicer is required for chromosome segregation and gene silencing in fission yeast cells
    Provost, P
    Silverstein, RA
    Dishart, D
    Walfridsson, J
    Djupedal, I
    Kniola, B
    Wright, A
    Samuelsson, B
    Rådmark, O
    Ekwall, K
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (26) : 16648 - 16653
  • [8] RETRACTED: Hairpin RNAs and retrotransposon LTRs effect RNAi and chromatin-based gene silencing (Retracted Article. See vol 301, pg 1069, 2003)
    Schramke, V
    Allshire, R
    [J]. SCIENCE, 2003, 301 (5636) : 1069 - 1074
  • [9] VERDEL A, 2004, SCIENCE
  • [10] RNA interference is required for normal centromere function in fission yeast
    Volpe, T
    Schramke, V
    Hamilton, GL
    White, SA
    Teng, G
    Martienssen, RA
    Allshire, RC
    [J]. CHROMOSOME RESEARCH, 2003, 11 (02) : 137 - 146