Synthesis of fluorescent, photolabile 3′-O-protected nucleoside triphosphates for the base addition sequencing scheme

被引:15
作者
Welch, MB [1 ]
Burgess, K [1 ]
机构
[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA
来源
NUCLEOSIDES & NUCLEOTIDES | 1999年 / 18卷 / 02期
关键词
D O I
10.1080/15257779908043067
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The dansylated nucleoside triphosphates la and Ib were prepared as a prelude to investigating sequencing of DNA via a scheme that does not involve electrophoresis.
引用
收藏
页码:197 / 201
页数:5
相关论文
共 9 条
[1]   DNA-POLYMERASE FLUORESCENT SUBSTRATES WITH REVERSIBLE 3'-TAGS [J].
CANARD, B ;
SARFATI, RS .
GENE, 1994, 148 (01) :1-6
[2]  
CHEESMAN PC, 1994, Patent No. 5302509
[3]   Model studies for new o-nitrobenzyl photolabile linkers: Substituent effects on the rates of photochemical cleavage [J].
Holmes, CP .
JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (08) :2370-2380
[4]   RAPID AND EFFICIENT SYNTHESIS OF NUCLEOSIDE 5'-O-(1-THIOTRIPHOSPHATES), 5'-TRIPHOSPHATES AND 2',3'-CYCLOPHOSPHOROTHIOATES USING 2-CHLORO-4H-1,3,2-BENZODIOXAPHOSPHORIN-4-ONE [J].
LUDWIG, J ;
ECKSTEIN, F .
JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (03) :631-635
[5]   TERMINATION OF DNA-SYNTHESIS BY NOVEL 3'-MODIFIED-DEOXYRIBONUCLEOSIDE 5'-TRIPHOSPHATES [J].
METZKER, ML ;
RAGHAVACHARI, R ;
RICHARDS, S ;
JACUTIN, SE ;
CIVITELLO, A ;
BURGESS, K ;
GIBBS, RA .
NUCLEIC ACIDS RESEARCH, 1994, 22 (20) :4259-4267
[6]  
ROSENTHAL A, 1993, Patent No. 9321340
[7]  
TSIEN RY, 1991, Patent No. 9106678
[8]  
WILHELM A, 1993, Patent No. 4141178
[9]   SYNTHESIS OF OLIGONUCLEOTIDES CONTAINING 3'-ALKYL CARBOXYLIC-ACIDS USING UNIVERSAL, PHOTOLABILE SOLID-PHASE SYNTHESIS SUPPORTS [J].
YOO, DJ ;
GREENBERG, MM .
JOURNAL OF ORGANIC CHEMISTRY, 1995, 60 (11) :3358-3364