Expression of uncoupling protein-3 and mitochondrial activity in the transition from hypothyroid to hyperthyroid state in rat skeletal muscle

被引：104

作者：

Lanni, A

Beneduce, L

Lombardi, A

Moreno, M

Boss, O

Muzzin, P

Giacobino, JP

Goglia, F

机构：

[1] Dipartimento Fisiol Gen & Ambientale, I-80134 Naples, Italy

[2] Seconda Univ Naples, Dipartimento Sci Vita, Caserta, Italy

[3] Univ Sannio, Fac Sci, Benevento, Italy

[4] Univ Geneva 1, Fac Med, Dept Biochem Med, Geneva, Switzerland

来源：

FEBS LETTERS | 1999年 / 444卷 / 2-3期

关键词：

uncoupling protein; thyroid hormone; skeletal muscle; mitochondrion; membrane potential;

D O I：

10.1016/S0014-5793(99)00061-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We sought a correlation between rat skeletal muscle triiodothyronine (T3)-mediated regulation of uncoupling protein-3 (UCP3) expression and mitochondrial activity, UCP3 mRNA expression increased strongly during the hypothyroid-hyperthyroid transition. The rank order of mitochondrial State 3 and State 4 respiration rates was hypothyroid < euthyroid < hyperthyroid. The State 4 increase may have been due to the increased UCP3 expression, as the proton leak kinetic was stimulated in the hypothyroid-hyperthyroid transition and a good correlation exists between the State 4 and UCP3 mRNA level. As a significant proportion of an organism's resting oxygen consumption is dedicated to opposing the proton leak, skeletal muscle mitochondrial UCP3 may mediate part of T3's effect on energy metabolism. (C) 1999 Federation of European Biochemical Societies.

引用

页码：250 / 254

页数：5

共 37 条

[1] Decrease in mitochondrial energy couplings by thyroid hormones: a physiological effect rather than a pathological hyperthyroidism consequence [J].