Transport proteins of Plasmodium falciparum:: defining the limits of metabolism

被引：14

作者：

Krishna, S ^{[1
]}

Webb, R ^{[1
]}

Woodrow, C ^{[1
]}

机构：

[1] Univ London St Georges Hosp, Sch Med, Sch Med, Dept Infect Dis, London SW17 0RE, England

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2001年 / 31卷 / 12期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

Plasmodium falciparum; Xenopusoocyte; malaria infected erythrocyte; parasite plasma membrane; 'P'-type ATPase; hexose transporter;

D O I：

10.1016/S0020-7519(01)00254-5

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

In this review we give an account of transport processes occurring at the membrane interface that separates the asexual stage of Plasmodium falciparum from its host, the infected erythrocyte, and also describe proteins whose activities may be important at this location. We explain the potential clinical value of such studies in the light of the current spread of parasite resistance to conventional antimalarial strategies. We discuss the uptake of substrates critical to the survival of the intracellular malaria parasite, and also the parasite's homeostatic and disposal mechanisms. The use of the Xenopus laevis expression system in the characterisation of a hexose transporter ('PfHT1') and a Ca2+ ATPase ('PfATP4') of the parasite plasma membrane are described in detail. (C) 2001 Australian Society for Parasitology Inc. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1331 / 1342

页数：12

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