The recombinant phage lysin LysK has a broad spectrum of lytic activity against clinically relevant Staphylococci, including methicillin-resistant Staphylococcus aureus

被引：177

作者：

O'Flaherty, S

Coffey, A

Meaney, W

Fitzgerald, GF

Ross, RP ^{[1
]}

机构：

[1] TEAGASC, Dairy Prod Res Ctr, Fermoy, Cork, Ireland

[2] Univ Coll Cork, Dept Microbiol, Cork, Ireland

[3] Cork Inst Technol, Dept Biol Sci, Cork, Ireland

[4] Alimentary Pharmabiot Ctr, Cork, Ireland

来源：

JOURNAL OF BACTERIOLOGY | 2005年 / 187卷 / 20期

关键词：

D O I：

10.1128/JB.187.20.7161-7164.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

This study concerns the cloning, characterization, and expression of the lysin (LysK) from staphylococcal phage K in Lactococcus lactis. Lactococcal lysates containing recombinant LysK were found to inhibit a range of different species of staphylococci isolated from bovine and human infection sources, including methicillin-resistant Staphylococcus aureus. LysK thus has potential as an antimicrobial for applications in the prevention and/or treatment of infections caused by staphylococci.

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收藏

页码：7161 / 7164

页数：4

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