Performance of a T-cell-based diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count

被引：123

作者：

Dheda, K ^{[1
]}

Lalvani, A

Miller, RF

Scott, G

Booth, H

Johnson, MA

Zumla, A

Rook, GAW

机构：

[1] UCL, Royal Free & Univ Coll Med Sch, Dept Populat Sci & Primary Care, Ctr Infect Dis & Int Hlth, London, England

[2] UCL, Royal Free & Univ Coll Med Sch, Dept Populat Sci & Primary Care, Ctr Sexual Hlth & HIV Res, London, England

[3] Univ Oxford, Nuffield Dept Clin Med, Oxford, England

[4] UCL Hosp NHS Trust, Dept Thorac Med, London, England

[5] Royal Free Hosp NHS Trust, Dept Thorac & HIV Med, London, England

来源：

AIDS | 2005年 / 19卷 / 17期

关键词：

D O I：

10.1097/01.aids.0000191923.08938.5b

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The performance characteristics of the enzyme-linked immunospot assay (ELISPOT) assay (T-SPOT TB) for the diagnosis of latent tuberculosis infection in HIV-infected individuals are unknown. Given that ELISPOT enumerates Mycobacterium tuberculosis antigen-specific IFN-gamma-secreting T cells, HIV-associated immunosuppression might adversely affect test performance. However, we found that 28 out of 29 HIV-positive individuals (97%) gave evaluable test results, and performance was independent of the CD4 T-cell count. ELlSPOT test performance appears to be independent of HIV-associated immunosuppression.

引用

页码：2038 / 2041

页数：4

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