Functional Properties of Tooth Pulp Neurons Responding to Thermal Stimulation

被引:14
作者
Ahn, D. K. [1 ]
Doutova, E. A. [2 ]
McNaughton, K. [3 ]
Light, A. R. [4 ]
Narhi, M. [5 ]
Maixner, W. [2 ]
机构
[1] Kyungpook Natl Univ, Sch Dent, Dept Oral Physiol, Taegu, South Korea
[2] Univ N Carolina, Ctr Neurosensory Disorders, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Dept Cell & Mol Physiol, Chapel Hill, NC 27599 USA
[4] Univ Utah, Dept Anesthesiol & Neurobiol, Salt Lake City, UT USA
[5] Univ Eastern Finland, Inst Biomed, Kuopio, Finland
关键词
tooth pulp neuron; trigeminal; sensitization; thermal stimulation; dental pain; tooth; MEDULLARY DORSAL-HORN; ELECTRICAL-STIMULATION; CENTRAL SENSITIZATION; TRIGEMINOTHALAMIC NEURONS; NOCICEPTIVE NEURONS; CENTRAL PROJECTIONS; HEAT STIMULATION; RESPONSES; RAT; AFFERENTS;
D O I
10.1177/0022034511435703
中图分类号
R78 [口腔科学];
学科分类号
100302 [口腔临床医学];
摘要
The response properties of tooth pulp neurons that respond to noxious thermal stimulation of the dental pulp have been not well-studied. The present study was designed to characterize the response properties of tooth pulp neurons to noxious thermal stimulation of the dental pulp. Experiments were conducted on 25 male ferrets, and heat stimulation was applied by a computer-controlled thermode. Only 15% of tooth pulp neurons (n = 39) responded to noxious thermal stimulation of the teeth. Tooth pulp neurons were found in both the superficial and deep nuclear regions of the subnucleus caudalis (Vc) and in the interface between the nucleus caudalis and interpolaris (Vc/Vi). Thirty-seven neurons had cutaneous receptive fields and were classified as either NS (16) or WDR (21) neurons. Repeated heat stimulation of the dental pulp sensitized and increased the number of electrically evoked potentials of tooth pulp neurons. These results provide evidence that both the Vc and Vc/Vi regions contain neurons that respond to noxious thermal stimulation of the dental pulp, and that these cells may contribute to the sensitization process associated with symptomatic pulpitis.
引用
收藏
页码:401 / 406
页数:6
相关论文
共 28 条
[1]
INFLUENCE OF LOCAL NOXIOUS HEAT STIMULATION ON SENSORY NERVE ACTIVITY IN FELINE DENTAL-PULP [J].
AHLBERG, KF .
ACTA PHYSIOLOGICA SCANDINAVICA, 1978, 103 (01) :71-80
[2]
A novel computerized system for thermal stimulation of tooth in ferrets [J].
Ahn, Dong K. ;
Monbureau, Ollie ;
Narhi, Matti ;
Maixner, William .
JOURNAL OF NEUROSCIENCE METHODS, 2012, 203 (02) :305-310
[3]
AN HRP STUDY OF THE CENTRAL PROJECTIONS OF PRIMARY TRIGEMINAL NEURONS WHICH INNERVATE TOOTH PULPS IN THE CAT [J].
ARVIDSSON, J ;
GOBEL, S .
BRAIN RESEARCH, 1981, 210 (1-2) :1-16
[4]
RESPONSE OF UNMYELINATED (C) POLYMODAL NOCICEPTORS TO THERMAL STIMULI APPLIED TO MONKEYS FACE [J].
BEITEL, RE ;
DUBNER, R .
JOURNAL OF NEUROPHYSIOLOGY, 1976, 39 (06) :1160-1175
[5]
Effects of cardiac vagal afferent electrostimulation on the responses of trigeminal and trigeminothalamic neurons to noxious orofacial stimulation [J].
Bossut, DF ;
Maixner, W .
PAIN, 1996, 65 (01) :101-109
[6]
THRESHOLDS TO ELECTRICAL-STIMULATION OF NERVES IN CAT CANINE TOOTH-PULP WITH A-BETA-FIBER,A-DELTA-FIBER AND C-FIBER CONDUCTION VELOCITIES [J].
CADDEN, SW ;
LISNEY, SJW ;
MATTHEWS, B .
BRAIN RESEARCH, 1983, 261 (01) :31-41
[7]
The effect of fentanyl on c-fos expression in the trigeminal brainstem complex produced by pulpal heat stimulation in the ferret [J].
Chattipakorn, SC ;
Light, AR ;
Willcockson, HH ;
Närhi, M ;
Maixner, W .
PAIN, 1999, 82 (02) :207-215
[8]
PHYSIOLOGICAL-PROPERTIES OF INTRADENTAL MECHANORECEPTORS [J].
DONG, WK ;
CHUDLER, EH ;
MARTIN, RF .
BRAIN RESEARCH, 1985, 334 (02) :389-395
[9]
PULPAL AXONS IN DEVELOPING, MATURE, AND AGING FELINE PERMANENT INCISORS - A STUDY BY ELECTRON-MICROSCOPY [J].
FRIED, K ;
HILDEBRAND, C .
JOURNAL OF COMPARATIVE NEUROLOGY, 1981, 203 (01) :23-36
[10]
AN EXPERIMENTAL INVESTIGATION INTO LOCALIZATION OF PAIN FROM DENTAL PULP [J].
FRIEND, LA ;
GLENWRIGHT, HD .
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 1968, 25 (05) :765-+