A new synthesis of 3,4,3-LI-1,2-HOPO (1,5,10,14-tetra(1-hydroxy-2-pyridone-6 oyl)-1,5,10,14-tetraazatetradecane)

被引：13

作者：

Bailly, T ^{[1
]}

Burgada, R ^{[1
]}

机构：

[1] Univ Paris 06, URA CNRS 473, Lab Chim Organoelements, F-75252 Paris 05, France

来源：

COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE II FASCICULE C-CHIMIE | 1998年 / 1卷 / 04期

关键词：

chelating agents; actinides; hydroxypyridinone; synthesis; decorporation; LIHOPO;

D O I：

10.1016/S1387-1609(98)80041-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

3,4,3 LI 1,2 HOPO is a very efficient ligand to remove actinides from the body after simulated contamination. Unfortunately the synthesis is not easy and the yield is small (15%). In this work we present a new facile synthesis with a good yield based on a protection-deprotection procedure of carboxyle and nitroxyde groups of the pyridone 1 and a phase transfer reaction for the peptide coupling step. (C) Academie des Sciences/Elsevier, Paris.

引用

页码：241 / 245

页数：5

共 15 条

[1] SOME ASPECTS OF THE BIOINORGANIC CHEMISTRY OF THE ACTINIDES [J].

BULMAN, RA .

COORDINATION CHEMISTRY REVIEWS, 1980, 31 (03) :221-250

[2] Intramolecular catalysis of amide isomerization [J].

Cox, C ;

Young, VG ;

Lectka, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (09) :2307-2308

[3]

GRAY SA, 1994, RADIAT PROT DOSIM, V53, P319

[4]

GREENE TW, 1981, PROTECTIVE GROUPS OR

[5] Different folding patterns of two similar triamides: A sharp contrast in their intramolecular amide-amide hydrogen-bonding propensity [J].

Gung, BW ;

Zhu, ZH .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (08) :2324-2325

[6] EFFICACY OF 3,4,3-LIHOPO FOR REDUCING THE RETENTION OF URANIUM IN RAT AFTER ACUTE ADMINISTRATION [J].

HENGENAPOLI, MH ;

ARCHIMBAUD, M ;

ANSOBORLO, E ;

METIVIER, H ;

GOURMELON, P .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1995, 68 (04) :389-393

[7]

Kocienski P.J., 1994, PROTECTING GROUPS

[8] STRUCTURE AND CHEMICAL-PROPERTIES OF PTILOMYCALIN-A [J].

OHTANI, I ;

KUSUMI, T ;

KAKISAWA, H ;

KASHMAN, Y ;

HIRSH, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (22) :8472-8479

[9]

PAQUET F, 1994, RADIAT PROT DOSIM, V53, P323

[10]

RAYMOND KN, 1981, STRUCT BOND, V43, P159

← 1 2 →