Orally administered combined regimens for treatment of Mycobacterium ulcerans infection in mice

被引：44

作者：

Ji, Baohong ^{[1
]}

Chauffour, Aurelie ^{[1
]}

Robert, Jerome ^{[1
]}

Lefrancois, Sebastien ^{[1
]}

Jarlier, Vincent ^{[1
]}

机构：

[1] Univ Paris 06, Fac Med Pierre & Marie Curie, F-75634 Paris 13, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 10期

关键词：

D O I：

10.1128/AAC.00730-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Eight weeks of treatment with rifampin-streptomycin sterilizes Mycobacterium ulcerans infection in mice. Because the bactericidal activity against M. ulcerans of the combination rifampin-moxifloxacin, rifampin-clarithromycin, or moxiffoxacin-clarithromycin was similar to that of rifampin-streptomycin, these combinations might be considered as alternative, orally administered combined regimens for treatment of Buruli ulcer in humans.

引用

页码：3737 / 3739

页数：3

共 6 条

[1]

CHAUTY A, 2007, ANTIMICORB AGENTS CH

[2] Efficacy of the combination rifampin-streptomycin in preventing growth of Mycobacterium ulcerans in early lesions of buruli ulcer in humans [J].

Etuaful, S ;

Carbonnelle, B ;

Grosset, J ;

Lucas, S ;

Horsfield, C ;

Phillips, R ;

Evans, A ;

Ofori-Adjei, D ;

Klustse, E ;

Owusu-Boaten, J ;

Amedofu, GK ;

Awuah, P ;

Arnpadu, E ;

Amofah, G ;

Asiedu, K ;

Wansbrough-Jones, A .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2005, 49 (08) :3182-3186

[3] In vitro and in vivo activities of rifampin, streptomycin, amikacin, moxifloxacin, R207910, linezolid, and PA-824 against Mycobacterium ulcerans [J].

Ji, Baohong ;

Lefrancois, Sebastien ;

Robert, Jerome ;

Chauffour, Aurelie ;

Truffot, Chantal ;

Jarlier, Vincent .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (06) :1921-1926

[4] Curing Mycobactetium ulcerans infection in mice with a combination of rifampin-streptomycin or rifampin-amikacin [J].

Lefrancois, Sebastien ;

Robert, Jerome ;

Chauffour, Aurelie ;

Ji, Baohong ;

Jarlier, Vincent .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2007, 51 (02) :645-650

[5] Isolation of three Mycobacterium ulcerans strains resistant to rifampin after experimental chemotherapy of mice [J].

Marsollier, L ;

Honoré, N ;

Legras, P ;

Manceau, AL ;

Kouakou, H ;

Carbonnelle, B ;

Cole, ST .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (04) :1228-1232

[6]

*WHO, 2004, PROV GUID ROL SPEC A

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