Neuromuscular responses to pyridostigmine bromide in organotypic spinal cord-muscle culture

被引：2

作者：

Drake-Baumann, R

Seil, FJ

Spencer, PS ^{[1
]}

机构：

[1] Oregon Hlth Sci Univ, Dept Neurol, Portland, OR 97201 USA

[2] Oregon Hlth Sci Univ, Dept Vet Affairs Med Ctr, Portland, OR 97201 USA

[3] Oregon Hlth Sci Univ, Sch Med, Portland, OR 97201 USA

[4] Oregon Hlth Sci Univ, Ctr Res Occupat & Environm Toxicol, Portland, OR 97201 USA

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 3-4期

关键词：

pyridostigmine bromide; neurotoxicity; muscle contractility; junctional myopathy; organotypic tissue culture; Gulf War unexplained illness;

D O I：

10.1016/S0928-4257(98)80038-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pyridostigmine bromide (PB) promotes and then silences cholinergic muscle activity, and disrupts the junctional regions of muscle fibers and associated nerve terminals, in organotypic mouse spinal cord-muscle cultures continuously treated with low concentrations of the drug for up to 14 days. Spontaneous muscle activity is restored within 1 week of drug removal. ((C)Elsevier, Paris).

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收藏

页码：305 / 308

页数：4

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