Protein conformation dictates prion strain

被引：15

作者：

Aguzzi, A ^{[1
]}

机构：

[1] Univ Spital Zurich, Inst Neuropathol, CH-8091 Zurich, Switzerland

来源：

NATURE MEDICINE | 1998年 / 4卷 / 10期

关键词：

D O I：

10.1038/2621

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new conformation-based immunoassay provides a smart and sensitive way of differentiating between strains of prions, the infectious particles believed to cause spongiform encephalopathy (pages 1157–1165 ).

引用

页码：1125 / 1126

页数：2

共 11 条

[1] BIOCHEMICAL AND PHYSICAL-PROPERTIES OF THE PRION PROTEIN FROM 2 STRAINS OF THE TRANSMISSIBLE MINK ENCEPHALOPATHY AGENT
BESSEN, RA
MARSH, RF
[J]. JOURNAL OF VIROLOGY, 1992, 66 (04) : 2096 - 2101
[2] Transmissions to mice indicate that 'new variant' CJD is caused by the BSE agent
Bruce, ME
Will, RG
Ironside, JW
McConnell, I
Drummond, D
Suttie, A
McCardle, L
Chree, A
Hope, J
Birkett, C
Cousens, S
Fraser, H
Bostock, CJ
[J]. NATURE, 1997, 389 (6650) : 498 - 501
[3] Prion diseases - BSE and prions: Uncertainties about the agent
Chesebro, B
[J]. SCIENCE, 1998, 279 (5347) : 42 - 43
[4] Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD
Collinge, J
Sidle, KCL
Meads, J
Ironside, J
Hill, AF
[J]. NATURE, 1996, 383 (6602) : 685 - 690
[5] Straining the prion hypothesis
Farquhar, CF
Somerville, RA
Bruce, ME
[J]. NATURE, 1998, 391 (6665) : 345 - 346
[6] The same prion strain causes vCJD and BSE
Hill, AF
Desbruslais, M
Joiner, S
Sidle, KCL
Gowland, I
Collinge, J
Doey, LJ
Lantos, P
[J]. NATURE, 1997, 389 (6650) : 448 - 450
[7] Molecular basis of phenotypic variability in sporadic Creutzfeldt-Jakob disease
Parchi, P
Castellani, R
Capellari, S
Ghetti, B
Young, K
Chen, SG
Farlow, M
Dickson, DW
Sima, AAF
Trojanowski, JQ
Petersen, RB
Gambetti, P
[J]. ANNALS OF NEUROLOGY, 1996, 39 (06) : 767 - 778
[8] NOVEL PROTEINACEOUS INFECTIOUS PARTICLES CAUSE SCRAPIE
PRUSINER, SB
[J]. SCIENCE, 1982, 216 (4542) : 136 - 144
[9] Eight prion strains have PrPSc molecules with different conformations
Safar, J
Wille, H
Itrri, V
Groth, D
Serban, H
Torchia, M
Cohen, FE
Prusiner, SB
[J]. NATURE MEDICINE, 1998, 4 (10) : 1157 - 1165
[10] Evidence for the conformation of the pathologic isoform of the prion protein enciphering and propagating prion diversity
Telling, GC
Parchi, P
DeArmond, SJ
Cortelli, P
Montagna, P
Gabizon, R
Mastrianni, J
Lugaresi, E
Gambetti, P
Prusiner, SB
[J]. SCIENCE, 1996, 274 (5295) : 2079 - 2082

← 1 2 →