Functional significance of histone deacetylase diversity

被引：327

作者：

Khochbin, S ^{[1
]}

Verdel, A ^{[1
]}

Lemercier, C ^{[1
]}

Seigneurin-Berny, D ^{[1
]}

机构：

[1] Inst Albert Bonniot, Fac Med, Lab Biol Mol & Cellulaire Differenciat, F-38706 Grenoble, France

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2001年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(00)00174-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Nucleocytoplasmic shuttling of histone deacetylases is emerging as a major step in determining the composition, and hence the activity, of the corresponding nuclear regulatory complexes. This shuffling process is one of the distinctive characteristics of these enzymes, themselves belonging to structurally and functionally different classes. Considering the specific features of each class of deacetylases, it is possible to determine how each member can contribute to particular cellular functions.

引用

页码：162 / 166

页数：5

共 49 条

[1] Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2 [J].

Afshar, G ;

Murnane, JP .

GENE, 1999, 234 (01) :161-168

[2] NuRD and SIN3 - histone deacetylase complexes in development [J].

Ahringer, J .

TRENDS IN GENETICS, 2000, 16 (08) :351-356

[3] THE SIR2 GENE FAMILY, CONSERVED FROM BACTERIA TO HUMANS, FUNCTIONS IN SILENCING, CELL-CYCLE PROGRESSION, AND CHROMOSOME STABILITY [J].

BRACHMANN, CB ;

SHERMAN, JM ;

DEVINE, SE ;

CAMERON, EE ;

PILLUS, L ;

BOEKE, JD .

GENES & DEVELOPMENT, 1995, 9 (23) :2888-2902

[4] Signaling to chromatin through histone modifications [J].

Cheung, P ;

Allis, CD ;

Sassone-Corsi, P .

CELL, 2000, 103 (02) :263-271

[5] Identification of a nuclear domain with deacetylase activity [J].

Downes, M ;

Ordentlich, P ;

Kao, HY ;

Alvarez, JGA ;

Evans, RM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (19) :10330-10335

[6] A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p [J].

Fischle, W ;

Emiliani, S ;

Hendzel, MJ ;

Nagase, T ;

Nomura, N ;

Voelter, W ;

Verdin, E .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (17) :11713-11720

[7] Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins [J].

Frye, RA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 273 (02) :793-798

[8] 14-3-3 proteins: Structure, function, and regulation [J].

Fu, HA ;

Subramanian, RR ;

Masters, SC .

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2000, 40 :617-647

[9] Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin [J].

Furumai, R ;

Komatsu, Y ;

Nishino, N ;

Khochbin, S ;

Yoshida, M ;

Horinouchi, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (01) :87-92

[10] Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization [J].

Grozinger, CM ;

Schreiber, SL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (14) :7835-7840

← 1 2 3 4 5 →