Non thiazolidinedione antihyperglycaemic agents .2. alpha-carbon substituted beta-phenylpropanoic acids

被引：37

作者：

Buckle, DR

Cantello, BCC

Cawthorne, MA

Coyle, PJ

Dean, DK

Faller, A

Haigh, D

Hindley, RM

Jefcott, LJ

Lister, CA

Pinto, IL

Rami, HK

Smith, DG

Smith, SA

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT MED CHEM,EPSOM KT18 5XQ,SURREY,ENGLAND

[2] SMITHKLINE BEECHAM PHARMACEUT,DEPT VASC BIOL,EPSOM KT18 5XQ,SURREY,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 17期

关键词：

D O I：

10.1016/0960-894X(96)00382-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The thiazolidine-2,4-dione ring of insulin sensitising antidiabetic agents can be replaced by alpha-acyl-, alpha-alkyl- and alpha-(aralkyl)-carboxylic acids. Inclusion of an additional lipophilic moiety affords compounds 14 and 16, equipotent to BRL 48482. Copyright (C) 1996 Elsevier Science Ltd

引用

收藏

页码：2127 / 2130

页数：4

相关论文

共 8 条

[1] [[OMEGA-(HETEROCYCLYLAMINO)ALKOXY]BENZYL]-2,4-THIAZOLIDINEDIONES AS POTENT ANTIHYPERGLYCEMIC AGENTS [J].

CANTELLO, BCC ;

CAWTHORNE, MA ;

COTTAM, GP ;

DUFF, PT ;

HAIGH, D ;

KINDLEY, RM ;

LISTER, CA ;

SMITH, SA ;

THURLBY, PL .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (23) :3977-3985

[2] 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J(2) IS A LIGAND FOR THE ADIPOCYTE DETERMINATION FACTOR PPAR-GAMMA [J].

FORMAN, BM ;

TONTONOZ, P ;

CHEN, J ;

BRUN, RP ;

SPIEGELMAN, BM ;

EVANS, RM .

CELL, 1995, 83 (05) :803-812

[3]

HAIGH D, 1994, Patent No. 13650

[4] AN ANTIDIABETIC THIAZOLIDINEDIONE IS A HIGH-AFFINITY LIGAND FOR PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA(PPAR-GAMMA) [J].

LEHMANN, JM ;

MOORE, LB ;

SMITHOLIVER, TA ;

WILKISON, WO ;

WILLSON, TM ;

KLIEWER, SA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (22) :12953-12956

[5]

RAMI HK, 1995, Patent No. 3288

[6] SILANE REDUCTIONS IN ACIDIC MEDIA .2. REDUCTIONS OF ARYL ALDEHYDES AND KETONES BY TRIALKYLSILANES IN TRIFLUOROACETIC ACID - SELECTIVE METHOD FOR CONVERTING CARBONYL GROUP TO METHYLENE [J].

WEST, CT ;

DONNELLY, SJ ;

KOOISTRA, DA ;

DOYLE, MP .

JOURNAL OF ORGANIC CHEMISTRY, 1973, 38 (15) :2675-2681

[7] The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones [J].

Willson, TM ;

Cobb, JE ;

Cowan, DJ ;

Wiethe, RW ;

Correa, ID ;

Prakash, SR ;

Beck, KD ;

Moore, LB ;

Kliewer, SA ;

Lehmann, JM .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (03) :665-668

[8] STUDIES ON HINDERED PHENOLS AND ANALOGS .1. HYPOLIPIDEMIC AND HYPOGLYCEMIC AGENTS WITH ABILITY TO INHIBIT LIPID-PEROXIDATION [J].

YOSHIOKA, T ;

FUJITA, T ;

KANAI, T ;

AIZAWA, Y ;

KURUMADA, T ;

HASEGAWA, K ;

HORIKOSHI, H .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (02) :421-428