Genetics of autism: Complex aetiology for a heterogeneous disorder

被引：544

作者：

Folstein, SE

Rosen-Sheidley, B

机构：

[1] Tufts Univ New England Med Ctr, Dept Psychiat, Boston, MA 02111 USA

[2] Tufts Univ, Sch Med, Dept Psychiat, Boston, MA 02111 USA

来源：

NATURE REVIEWS GENETICS | 2001年 / 2卷 / 12期

关键词：

D O I：

10.1038/35103559

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Since autism was first recognized as a disorder in 1943, speculation about its aetiology has ranged from biological to psychological and back again, After twin studies during the 1970s and 1980s yielded unequivocal evidence for a genetic component, aetiological research in autism began to focus primarily on uncovering the genetic mechanisms involved. The identification of chromosomal abnormalities and Mendelian syndromes among individuals with autism, In conjunction with data from genome screens and candidate-gene studies, has helped to refine the view of the complex genetics that underlies autism spectrum conditions.

引用

页码：943 / 955

页数：13

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