Two useful dimensionless parameters that combine physiological, operational and bioreactor design parameters for improved control of dissolved oxygen

被引：12

作者：

De León, A

Barba-de la Rosa, AP

Mayani, H

Galindo, E

Ramírez, OT

机构：

[1] Inst Tecnol Celaya, Dept Ingn Bioquim, Celaya 38010, Gto, Mexico

[2] Univ Nacl Autonoma Mexico, Dept Bioingn, Inst Biotecnol, Cuernavaca 62250, Morelos, Mexico

[3] Hosp Oncol, Ctr Med Nacl Siglo XXI, Mexico City, DF, Mexico

来源：

BIOTECHNOLOGY LETTERS | 2001年 / 23卷 / 13期

关键词：

bioreactor; dimensionless numbers; dissolved oxygen; hematopoietic cells; PID controller; recombinant E. coli;

D O I：

10.1023/A:1010598121587

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Two new dimensionless parameters (Phi and Omega) are proposed for calculating the proportional, integral, and derivative constants of a dissolved oxygen proportional integral-derivative (PID) feed-back control algorithm from knowledge of the growth rate, bioreactor design and operation variables. The values of Phi and Omega were determined for a broad range of Reynolds numbers (between 1000 to 40 000) during the exponential growth phase of two highly different processes: fermentations of recombinant Escherichia coli and cultures of human hematopoietic cells. The utility of Phi and Omega for use in dissolved oxygen self-tunning adaptive control algorithms is discussed.

引用

页码：1051 / 1056

页数：6

共 15 条

[1] DESIGN OF A SYSTEM FOR THE CONTROL OF LOW DISSOLVED-OXYGEN CONCENTRATIONS - CRITICAL OXYGEN CONCENTRATIONS FOR AZOTOBACTER-VINELANDII AND ESCHERICHIA-COLI [J].