HIV-1 neutralizing antibodies: How full is the bottle?

被引:76
作者
Moore, JP [1 ]
Burton, DR
机构
[1] Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA
[2] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Dept Mol Biol, La Jolla, CA 92037 USA
关键词
D O I
10.1038/5502
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Potent neutralizing antibodies protect monkeys from SHIV challenge, but will vaccines ever be able to elicit antibody responses this powerful? (pages 204–216)
引用
收藏
页码:142 / 144
页数:3
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共 17 条
  • [1] Induction of immune responses to HIV-1 by canarypox virus (ALVAC) HIV-1 and gp120 SF-2 recombinant vaccines in uninfected volunteers
    Belshe, RB
    Gorse, GJ
    Mulligan, MJ
    Evans, TG
    Keefer, MC
    Excler, JL
    Duliege, AM
    Tartaglia, J
    Cox, WI
    McNamara, J
    Hwang, KL
    Bradney, A
    Montefiori, D
    Weinhold, KJ
    [J]. AIDS, 1998, 12 (18) : 2407 - 2415
  • [2] Why do we not have an HIV vaccine and how can we make one?
    Burton, DR
    Moore, JP
    [J]. NATURE MEDICINE, 1998, 4 (05) : 495 - 498
  • [3] Immunological and virological analyses of persons infected by human immunodeficiency virus type 1 while participating in trials of recombinant gp120 subunit vaccines
    Connor, RI
    Korber, BTM
    Graham, BS
    Hahn, BH
    Ho, DD
    Walker, BD
    Neumann, AU
    Vermund, SH
    Mestecky, J
    Jackson, S
    Fenamore, E
    Cao, Y
    Gao, F
    Kalams, S
    Kunstman, KJ
    McDonald, D
    McWilliams, N
    Trkola, A
    Moore, JP
    Wolinsky, SM
    [J]. JOURNAL OF VIROLOGY, 1998, 72 (02) : 1552 - 1576
  • [4] PREVENTION OF HIV-1 INFECTION IN CHIMPANZEES BY GP120 V3 DOMAIN-SPECIFIC MONOCLONAL-ANTIBODY
    EMINI, EA
    SCHLEIF, WA
    NUNBERG, JH
    CONLEY, AJ
    EDA, Y
    TOKIYOSHI, S
    PUTNEY, SD
    MATSUSHITA, S
    COBB, KE
    JETT, CM
    EICHBERG, JW
    MURTHY, KK
    [J]. NATURE, 1992, 355 (6362) : 728 - 730
  • [5] Passive immunization with a human monoclonal antibody protects hu-PBL-SCID mice against challenge by primary isolates of HIV-1
    Gauduin, MC
    Parren, PWHI
    Weir, R
    Barbas, CF
    Burton, DR
    Koup, RA
    [J]. NATURE MEDICINE, 1997, 3 (12) : 1389 - 1393
  • [6] Human immunodeficiency virus type 1 neutralizing antibodies accelerate clearance of cell-free virions from blood plasma
    Igarashi, T
    Brown, C
    Azadegan, A
    Haigwood, N
    Dimitrov, D
    Martin, MA
    Shibata, R
    [J]. NATURE MEDICINE, 1999, 5 (02) : 211 - 216
  • [7] Progress in the development of an HIV-1 vaccine
    Letvin, NL
    [J]. SCIENCE, 1998, 280 (5371) : 1875 - 1880
  • [8] Neutralizing and infection-enhancing antibody responses to human immunodeficiency virus type 1 in long-term nonprogressors
    Montefiori, DC
    Pantaleo, G
    Fink, LM
    Zhou, JT
    Zhou, JY
    Bilska, M
    Miralles, GD
    Fauci, AS
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1996, 173 (01) : 60 - 67
  • [9] Neutralizing antibodies in sera from macaques infected with chimeric simian-human immunodeficiency virus containing the envelope glycoproteins of either a laboratory-adapted variant or a primary isolate of human immunodeficiency virus type 1
    Montefiori, DC
    Reimann, KA
    Wyand, MS
    Manson, K
    Lewis, MG
    Collman, RG
    Sodroski, JG
    Bolognesi, DP
    Letvin, NL
    [J]. JOURNAL OF VIROLOGY, 1998, 72 (04) : 3427 - 3431
  • [10] Limited breadth of the protective immunity elicited by simian immunodeficiency virus SIVmne gp160 vaccines in a combination immunization regimen
    Polacino, P
    Stallard, V
    Klaniecki, JE
    Montefiori, DC
    Langlois, AJ
    Richardson, BA
    Overbaugh, J
    Morton, WR
    Benveniste, RE
    Hu, SL
    [J]. JOURNAL OF VIROLOGY, 1999, 73 (01) : 618 - 630