Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI):: 2,9-disubstituted 1,2,3,4-tetrahydropyrido[3,4-b]indoles as potential antibacterial agents

被引：60

作者：

Seefeld, MA ^{[1
]}

Miller, WH ^{[1
]}

Newlander, KA ^{[1
]}

Burgess, WJ ^{[1
]}

Payne, DJ ^{[1
]}

Rittenhouse, SF ^{[1
]}

Moore, TD ^{[1
]}

DeWolf, WE ^{[1
]}

Keller, PM ^{[1
]}

Qiu, XY ^{[1
]}

Janson, CA ^{[1
]}

Vaidya, K ^{[1
]}

Fosberry, AP ^{[1
]}

Smyth, MG ^{[1
]}

Jaworski, DD ^{[1
]}

Slater-Radosti, C ^{[1
]}

Huffman, WF ^{[1
]}

机构：

[1] GlaxoSmithKline Pharmaceut, Antimicrobial & Host Def Div, Collegeville, PA 19426 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(01)00405-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An SAR study of a screening lead has led to the identification of 2,9-disubstituted 1, 2, 3, 4-tetrahydropyrido [3,4-b]indoles as inhibitors of Staphylococcus aureus enoyl acyl carrier protein reductase (FabI). (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2241 / 2244

页数：4

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