Computed Tomography Perfusion Imaging for Therapeutic Assessment Has It Come of Age as a Biomarker in Oncology?

被引：47

作者：

Goh, Vicky ^{[2
]}

Ng, Quan Sing ^{[3
]}

Miles, Ken ^{[1
]}

机构：

[1] Univ Sussex, Clin Imaging Sci Ctr, Brighton & Sussex Med Sch, Brighton BN1 9PX, E Sussex, England

[2] Kings Coll London, Div Imaging Sci, Sch Med, London WC2R 2LS, England

[3] Natl Canc Ctr, Dept Med Oncol, Singapore, Singapore

来源：

INVESTIGATIVE RADIOLOGY | 2012年 / 47卷 / 01期

关键词：

cancer; perfusion CT; response assessment; novel therapies; CT; RENAL-CELL CARCINOMA; TUMOR RESPONSE; MONOCLONAL-ANTIBODY; CT PERFUSION; LUNG-CANCER; BLOOD-FLOW; BEVACIZUMAB; CHEMOTHERAPY; SIZE; ATTENUATION;

D O I：

10.1097/RLI.0b013e318229ff3e

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

With the emergence of novel targeted therapies, imaging techniques that assess tumor vascular support have gained credence for response assessment alongside standard response criteria. Computed tomography (CT) perfusion techniques that quantify regional tumor blood flow, blood volume, flow-extraction product, and permeability-surface area product through standard kinetic models are attractive, but the level of evidence for CT perfusion to be a truly mature biomarker remains insufficient. Studies to date have not been powered to assess this. Future studies that include good quality prospective validation correlating perfusion CT to outcome end points in the trial setting are needed to take CT perfusion forward as a biomarker in oncology.

引用

页码：2 / 4

页数：3

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