Severe acute respiratory syndrome coronavirus fails to activate cytokine-mediated innate immune responses in cultured human monocyte-derived dendritic cells

被引：66

作者：

Ziegler, T ^{[1
]}

Matikainen, S ^{[1
]}

Rönkkö, E ^{[1
]}

Österlund, P ^{[1
]}

Sillanpää, M ^{[1
]}

Sirén, J ^{[1
]}

Fagerlund, R ^{[1
]}

Immonen, M ^{[1
]}

Melén, K ^{[1
]}

Julkunen, L ^{[1
]}

机构：

[1] Natl Publ Hlth Inst, Dept Viral Dis & Immunol, FIN-00300 Helsinki, Finland

来源：

JOURNAL OF VIROLOGY | 2005年 / 79卷 / 21期

关键词：

D O I：

10.1128/JVI.79.21.13800-13805.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Activation of host innate immune responses was studied in severe acute respiratory syndrome coronavirus (SCV)-infected human A549 lung epithelial cells, macrophages, and dendritic cells (DCs). In all cell types, SCV-specific subgenomic mRNAs were seen, whereas no expression of SCV proteins was found. No induction of cytokine genes (alpha interferon [IFN-alpha], IFN-beta, interleukin-28A/B [IL-28A/B], IL-29, tumor necrosis factor alpha, CCL5, or CXCL10) or IFN-alpha/beta-induced MxA gene was seen in SCV-infected A549 cells, macrophages, or DCs. SCV also failed to induce DC maturation (CD86 expression) or enhance major histocompatibility complex class II expression. Our data strongly suggest that SCV fails to activate host cell cytokine gene expression in human macrophages and DCs.

引用

页码：13800 / 13805

页数：6

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