Responsive and recognitive hydrogels using star polymers

被引：51

作者：

Oral, E ^{[1
]}

Peppas, NA

机构：

[1] Purdue Univ, Sch Chem Engn, W Lafayette, IN 47907 USA

[2] Univ Texas, Dept Chem Engn, Austin, TX 78712 USA

[3] Univ Texas, Dept Biomed Engn & Pharmaceut, Austin, TX 78712 USA

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2004年 / 68A卷 / 03期

关键词：

recognition; pH sensitive; molecular imprinting; modulated drug delivery;

D O I：

10.1002/jbm.a.20076

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Polymeric networks that have inherent capabilities to recognize different molecules and chemical changes in their environment are the next generation of materials that will aid in the diagnosis and treatment of diseases. We have prepared new networks based on star polymers that were designed to be responsive and recognitive. Using molecular imprinting with D-glucose and crosslinking with poly(ethylene glycol) dimethacrylate with an ethylene glycol chain of nominal molecular weight 600, we prepared star polymer networks, which exhibited over 300% more uptake for D-glucose compared to D-fructose. Using copolymerization with methacrylic acid, we prepared star polymer networks with pH-sensitivity, which showed a sharp transition in swelling around a pH of 4.5. (C) 2004 Wiley Periodicals, Inc.

引用

页码：439 / 447

页数：9

共 17 条

[1] DETERMINATION OF POLYMER SOLVENT INTERACTION PARAMETER FROM SWELLING OF NETWORKS - THE SYSTEM POLY(2-HYDROXYETHYL METHACRYLATE)-DIETHYLENE GLYCOL [J].