Effects of intrathecal galanin on nociceptive responses in rats with mononeuropathy

被引：41

作者：

Yu, LC ^{[1
]}

Lundeberg, S

An, H

Wang, FX

Lundeberg, T

机构：

[1] Peking Univ, Coll Life Sci, Dept Physiol, Beijing 100871, Peoples R China

[2] Peking Univ, Natl Lab Biomembranes & Membrane Biotechnol, Beijing 100871, Peoples R China

[3] Karolinska Inst, Dept Physiol & Pharmacol, S-17177 Stockholm, Sweden

[4] Karolinska Inst, Dept Surg & Rehabil, S-17177 Stockholm, Sweden

来源：

LIFE SCIENCES | 1999年 / 64卷 / 13期

基金：

中国国家自然科学基金;

关键词：

galanin; sciatic nerve loose ligation; mononeuropathy; hindpaw withdrawal latency; hot-plate test; cold-plate test; Randall Selitto test;

D O I：

10.1016/S0024-3205(99)00043-0

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The present study was performed on rats with experimental mononeuropathy induced by left common sciatic nerve loose ligation. Unilateral sciatic nerve loose ligation induced decreases of the hindpaw withdrawal latency to the hot-plate test, cold-plate test and the Randall Selitto test. Sciatic nerve loose ligation induced hyperesponsiveness to touch at room temperature also. Intrathecal administration of either 3 or 6 nmol of galanin, but not 1 nmol, induced significant bilateral increases in hindpaw withdrawal latencies to the hot-plate test, cold-plate test and the Randall Selitto tests in rats with left mononeuropathy. The results indicate that galanin may play important roles in transmission of presumed nociceptive information in the spinal cord of mononeuropathic rats.

引用

页码：1145 / 1153

页数：9

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