Immunosuppressive Properties of Mesenchymal Stem Cells

被引：240

作者：

Abumaree, Mohamed ^{[3
]}

Al Jumah, Mohammed ^{[3
]}

Pace, Rishika A. ^{[1
,2
]}

Kalionis, Bill ^{[1
,2
]}

机构：

[1] Univ Melbourne, Dept Perinatal Med Pregnancy Res Ctr, Royal Womens Hosp, Parkville, Vic 3052, Australia

[2] Univ Melbourne, Royal Womens Hosp, Dept Obstet & Gynaecol, Parkville, Vic 3052, Australia

[3] King Saud Bin Abdulaziz Univ Hlth Sci, King Abdullah Int Med Res Ctr, Riyadh 11426, Saudi Arabia

来源：

STEM CELL REVIEWS AND REPORTS | 2012年 / 8卷 / 02期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Stem cells; Immunosuppression; Mesenchymal stem cells; Immune modulation; HUMAN BONE-MARROW; VERSUS-HOST-DISEASE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; PROLIFERATION IN-VITRO; SUPPRESS T-LYMPHOCYTE; ERYTHROCYTE-P-ANTIGEN; HUMAN PARVOVIRUS B19; STROMAL CELLS; PERIPHERAL-BLOOD;

D O I：

10.1007/s12015-011-9312-0

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Mesenchymal stem cells (MSC) can be isolated from different adult tissues including bone marrow, adipose tissue, cord blood and placenta. MSCs modulate the immune function of the major immune cell populations involved in alloantigen recognition and elimination, including antigen presenting cells, T cells, B cells and natural killer cells. Many clinical trials are currently underway that employ MSCs to treat human immunological diseases. However, the molecular mechanism that mediates the immunosuppressive effect of MSCs is still unclear and the safety of using MSC in patient needs further confirmation. Here, we review the cytokines that activate MSCs and the soluble factors produced by MSCs, which allow them to exert their immunosuppressive effects. We review the mechanism responsible, at least in part, for the immune suppressive effects of MSCs and highlight areas of research required for a better understanding of MSC immune modulation.

引用

页码：375 / 392

页数：18

共 202 条

[1]

Human mesenchymal stem cells modulate allogeneic immune cell responses [J].