Renin-angiotensin system component gene polymorphism in Japanese bronchial asthma patients

被引：21

作者：

Nakahama, H ^{[1
]}

Obata, K ^{[1
]}

Nakajima, T ^{[1
]}

Nakamura, H ^{[1
]}

Kitada, O ^{[1
]}

Sugita, M ^{[1
]}

Fujita, Y ^{[1
]}

Kawada, N ^{[1
]}

Moriyama, T ^{[1
]}

机构：

[1] Hyogo Coll Med, Dept Internal Med 5, Nishinomiya, Hyogo 6638501, Japan

来源：

JOURNAL OF ASTHMA | 1999年 / 36卷 / 02期

关键词：

ACE I/D polymorphism; angiotensinogen T235/M235 polymorphism; bronchial asthma;

D O I：

10.3109/02770909909056316

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The influence of renin-angiotensin system (RAS) component gene polymorphism in the pathogenesis of bronchial asthma was investigated in an association study involving 119 bronchial asthma patients and 208 control subjects. The selected RAS polymorphisms were angiotensinogen (Agt) T235/M235 and angiotensin I-converting enzyme (ACE) insertion/deletion (I/D). The control allelic frequencies of the Agt T235/M235 (0.84/0.16) and ACE I/D (0.63/0.37) in this study were similar to the previous reports in Japanese normal population. The allelic frequencies of the Agt T235/M235 (0.84/0.16) and ACE I/D (0.65/0.35) among the asthma patients were not significantly different from those among the control subjects. There was no association between severity of bronchial asthma and the selected RAS component gene polymorphism. From these data, we conclude that in the Japanese population, the RAS component gene polymorphism is not associated with increased risk for bronchial asthma.

引用

页码：187 / 193

页数：7

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