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Wavelength and conduction inhomogeneity in each atrium in patients with isolated mitral valve disease and atrial fibrillation
被引:24
作者:
Nitta, T
[1
]
Imura, H
[1
]
Bessho, R
[1
]
Hosaka, H
[1
]
Yamauchi, S
[1
]
Tanaka, S
[1
]
机构:
[1] Nippon Med Sch, Dept Cardiothorac Surg, Bunkyo Ku, Tokyo 113, Japan
关键词:
atrial fibrillation;
mitral valve disease;
wavelength;
conduction inhomogeneity;
electrical remodeling;
D O I:
10.1111/j.1540-8167.1999.tb00708.x
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
AF in Mitral Valve Disease. Introduction: Patients with mitral valve disease frequently have atrial fibrillation (AF), and the left atrium is presumed to be the primary atrium that develops AF. However, it is still not clear whether the electrophysiologic abnormalities responsible for AF are confined to the left;atrium in this subset of patients. Methods and Results: To examine the AF vulnerability of each atrium, we measured the wavelength and inhomogeneity of the conduction at the lateral right atrium, lateral left atrium, and Bachmann's bundle after defibrillation of AF in seven patients undergoing the maze procedure and mitral valve surgery for AF and isolated mitral valve disease, respectively (AF group). The data were compared with five coronary surgery patients in sinus rhythm (SR group). The wavelength in the AF group was significantly shorter (P < 0.05) than in the SR group not only at the lateral left atrium (225 +/- 62 vs 285 +/- 36 mm) but also at the lateral right atrium (214 +/- 54 vs 254 +/- 34 mm). The variation coefficient of the local maximum activation phase difference in the AF group (1.9 +/- 0.8 art the right atrium, 2.1 +/- 0.8 at the lateral left atrium, and 2.0 +/- 0.6 at Bachmann's bundle) was significantly greater (P < 0.05) than in the SR group at all atrial regions. Conclusion: AF vulnerability was not confined to the left atrium immediately after defibrillation in AF patients with isolated mitral valve disease. Electrical remodeling resulting from perpetuation of AF, pathological changes extending to the right atrium, geometric changes caused by the atrial interactions occurring across the interatrial septum, or a combination of these may explain the results.
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页码:521 / 528
页数:8
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