ULBP4 is a novel ligand for human NKG2D

被引：137

作者：

Chalupny, NJ ^{[1
]}

Sutherland, CL ^{[1
]}

Lawrence, WA ^{[1
]}

Rein-Weston, A ^{[1
]}

Cosman, D ^{[1
]}

机构：

[1] Amgen Inc, Seattle, WA 98101 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 305卷 / 01期

关键词：

NK cell; cytotoxicity; MHC; ULBP; NKG2D;

D O I：

10.1016/S0006-291X(03)00714-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ULBPs are a family of MHC class I-related molecules. We have previously shown that ULBPs 1, 2, and 3 are functional ligands of the NKG2D/DAP10 receptor complex on human natural killer (NK) cells. Here, we describe a new member of the ULBP family. ULBP4, which contains predicted transmembrane and cytoplasmic domains, unlike the other ULBPs, which are GPI-linked proteins. Transduction of ULBP4 into EL4 cells confers the ability to bind recombinant NKG2D and mediates increased cytotoxic activity by human NK cells. consistent with the role of ULBPs as ligands for the NKG2D/DAP10 activating receptors. Tissue expression of ULBP4 differs from other members of the family, in that it is expressed predominantly in the skin. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：129 / 135

页数：7

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