MiR-107 is Reduced in Alzheimer's Disease Brain Neocortex: Validation Study

被引：190

作者：

Nelson, Peter T. ^{[1
]}

Wang, Wang-Xia

机构：

[1] Univ Kentucky, Dept Pathol, Div Neuropathol, Med Ctr, Lexington, KY 40536 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 21卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Amyloid; metabolism; neurodegeneration; noncoding; RTqPCR; tau; MICRORNAS; EXPRESSION; MIRNAS; NEURODEGENERATION; PATHWAYS; ABSENCE; CELLS; RNA;

D O I：

10.3233/JAD-2010-091603

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

MiR-107 is a microRNA (miRNA) that we reported previously to have decreased expression in the temporal cortical gray matter early in the progression of Alzheimer's disease (AD). Here we study a new group of well-characterized human temporal cortex samples (N = 19). MiR-107 expression was assessed, normalized to miR-124 and let-7a. Correlation was observed between decreased miR-107 expression and increased neuritic plaque counts (P < 0.05) and neurofibrillary tangle counts (P < 0.02) in adjacent brain tissue. Adjusted miR-107 and BACE1 mRNA levels tended to correlate negatively (trend with regression P < 0.07). In sum, miR-107 expression tends to be lower relative to other miRNAs as AD progresses.

引用

页码：75 / 79

页数：5

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