A beginner's guide to NF-κB signaling pathways

被引：81

作者：

Delhalle, S ^{[1
]}

Blasius, R ^{[1
]}

Dicato, M ^{[1
]}

Diederich, M ^{[1
]}

机构：

[1] Hop Kirchberg, Lab Biol Mol & Cellularie Canc, L-2540 Luxembourg, Luxembourg

来源：

SIGNAL TRANSDUCTION PATHWAYS, CHROMATIN STRUCTURE, AND GENE EXPRESSION MECHANISMS AS THERAPEUTIC TARGETS | 2004年 / 1030卷

关键词：

NF-kappa B; apoptosis; inflammation; cancer;

D O I：

10.1196/annals.1329.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nuclear factor KB (NF-KB) belongs to a family of heterodimeric transcription factors that play a key role in inflammatory and stress responses as well as in tumor cell resistance to apoptosis. These effects are due to the NF-KB-dependent transcription of many proinflammatory and antiapoptotic genes, whose products ensure various cell responses to environmental conditions. The signal transduction pathways leading to NF-KB activation are well characterized, and the different steps implicated in these pathways involve proteins that could constitute targets for NF-KB inhibition. Several inhibitors aiming to prevent NF-KB activity and thus the transcription of target genes are studied, and a few compounds seem particularly promising. We try here to summarize the advantages that can issue from various studies on NF-KB.

引用

页码：1 / 13

页数：13

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