Effect of cyclohexenonic long chain fatty alcohols on neurite outgrowth. Study on structure-activity relationship

被引：34

作者：

Girlanda-Junges, C ^{[1
]}

Keyling-Bilger, F ^{[1
]}

Schmitt, G ^{[1
]}

Luu, B ^{[1
]}

机构：

[1] Univ Strasbourg, Lab Chim Organ Subst Nat, UMR 7509 CNRS, Ctr Neurochim, F-67084 Strasbourg, France

来源：

TETRAHEDRON | 1998年 / 54卷 / 27期

关键词：

D O I：

10.1016/S0040-4020(98)00406-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four series of long chain fatty alcohols bearing a cyclohexenone moiety in addition to a omega-alkanol side chain were synthesized using "Umpolung" reactivity strategy. Their effect on neurite outgrowth was evaluated by means of fetal rat neurons in culture. The length of the omega-hydroxy side chain is a crucial factor for biological activity. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7735 / 7748

页数：14

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