The economic use of precious chiral diphosphine ligands-DuPHOS and its rhodium(I) COD and NBD complexes

被引：39

作者：

Börner, A ^{[1
]}

Heller, D ^{[1
]}

机构：

[1] Univ Rostock EV, Inst Organ Katalyseforsch, D-18055 Rostock, Germany

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 02期

关键词：

D O I：

10.1016/S0040-4039(00)01942-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The use of cationic Rh(DuPHOS) precatalysts for asymmetric hydrogenation bearing NBD (norbornadiene) as counter ligand has significant advantages over the application of the related COD (cyclooctadiene) complexes. Liberation of the active catalysts by hydrogenation of COD requires much more time than complete asymmetric hydrogenation of a prochiral substrate proceeding in parallel. Due to this feature expensive DuPHOS ligands are wasted by more than 50%. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：223 / 225

页数：3

共 31 条

[1] Enantioselective catalytic hydrogenation
Albrecht, J
Nagel, U
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1996, 35 (04): : 407 - 409
[2] ALBRECHT J, 1996, ANGEW CHEM, V108, P444
[3] [Anonymous], T METALS ORGANIC SYN
[4] Baumann W, 1997, MAGN RESON CHEM, V35, P701, DOI 10.1002/(SICI)1097-458X(199711)35:10<701::AID-OMR160>3.0.CO
[5] 2-Q
[6] Brown J. M, 1999, COMPREHENSIVE ASYMME, VI, P121
[7] BRUNNER H, 1996, APPL HOMOGENEOUS CAT, P201
[8] Asymmetric catalytic routes to chiral building blocks of medicinal interest
Burk, MJ
Gross, MF
Harper, TGP
Kalberg, CS
Lee, JR
Martinez, JP
[J]. PURE AND APPLIED CHEMISTRY, 1996, 68 (01) : 37 - 44
[9] Bis(phospholane) ligands containing chiral backbones.: Matching and mismatching effects in enantioselective hydrogenation of α-keto esters
Burk, MJ
Pizzano, A
Martín, JA
Liable-Sands, LM
Rheingold, AL
[J]. ORGANOMETALLICS, 2000, 19 (03) : 250 - 260
[10] Highly regio- and enantioselective catalytic hydrogenation of enamides in conjugated diene systems:: Synthesis and application of γ,δ-unsaturated amino acids
Burk, MJ
Allen, JG
Kiesman, WF
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (04) : 657 - 663

← 1 2 3 4 →