An Evidence-based Approach to the Medical Management of Fibroids: A Systematic Review

被引：50

作者：

Bartels, Chantal B. ^{[1
]}

Cayton, Kamaria C. ^{[2
]}

Chuong, Farah S. ^{[2
]}

Holthouser, Kristine ^{[3
]}

Mehr, Sara A. ^{[4
]}

Abraham, Tara ^{[5
]}

Segars, James H. ^{[2
]}

机构：

[1] Univ Connecticut, Sch Med, Dept Obstet & Gynecol, Farmington, CT USA

[2] Johns Hopkins Univ, Sch Med, Dept Gynecol & Obstet, Howard W & Georgeanna Seegar Jones Div Reprod Sc, 720 Rutland Ave,Ross Bldg,Room 624, Baltimore, MD 21205 USA

[3] Univ Louisville, Sch Med, Dept Obstet Gynecol & Womens Hlth, Louisville, KY 40292 USA

[4] Cleveland Clin, Dept Obstet & Gynecol, Cleveland, OH 44106 USA

[5] Foxhall OB GYN Associates, Washington, DC USA

来源：

CLINICAL OBSTETRICS AND GYNECOLOGY | 2016年 / 59卷 / 01期

基金：

美国国家卫生研究院;

关键词：

fibroids; leiomyoma; medical therapy; medical treatment; PROGESTERONE-RECEPTOR MODULATOR; DEPOT-MEDROXYPROGESTERONE ACETATE; SYMPTOMATIC UTERINE LEIOMYOMA; SHORT-TERM TREATMENT; PREMENOPAUSAL WOMEN; POSTMENOPAUSAL WOMEN; ULIPRISTAL ACETATE; LEUPROLIDE ACETATE; HYSTERECTOMY RATES; HORMONE AGONIST;

D O I：

10.1097/GRF.0000000000000171

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

Fibroids are the most common tumor of the female reproductive tract, but approved medical treatments are limited. Patients demand uterine-sparing treatments which preserve fertility and avoid surgery. We systematically reviewed PubMed and Cochrane databases from January 1985 to November 2015 for evidence-based medical therapies for fibroids in the context of disease prevention, treatment of early disease, treatment of symptomatic disease, and preoperative management. We identified 2182 studies, of which 52 studies met inclusion and exclusion criteria. Published data affirm the efficacy of multiple agents, which are promising avenues for the development of medical alternatives to surgery.

引用

页码：30 / 52

页数：23

共 115 条

[1]

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