Vaccine Immunopotentiators of the future

被引：28

作者：

Schijns, V. E. J. C. ^{[1
]}

Degen, W. G. J. ^{[1
]}

机构：

[1] Intervet Int BV, Dept Vaccine Technol & Immunol R&D, Boxmeer, Netherlands

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2007年 / 82卷 / 06期

关键词：

D O I：

10.1038/sj.clpt.6100394

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Vaccine adjuvants or immunopotentiators comprise a diverse group of molecules or formulations. Despite a wealth of different candidates, there is a need for better vaccine adjuvants in both veterinary and human medicine. For human vaccines, the immunopotentiator choice has been limited to aluminum salts, until recently. By contrast, a whole range of adjuvants is employed for inactivated veterinary vaccines, due to less stringent safety and regulatory requirements and proven superior vaccine performance. This review highlights recent developments and future trends in immunopotentiators.

引用

页码：750 / 755

页数：6

共 30 条

[1] Dendritic cells and the control of immunity [J].

Banchereau, J ;

Steinman, RM .

NATURE, 1998, 392 (6673) :245-252

[2] IFN-γ mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy [J].

Berner, Vanessa ;

Liu, Haiyan ;

Zhou, Qing ;

Alderson, Kory L. ;

Sun, Kai ;

Weiss, Jonathan M. ;

Back, Timothy C. ;

Longo, Dan L. ;

Blazar, Bruce R. ;

Wiltrout, Robert H. ;

Welniak, Lisbeth A. ;

Redelman, Doug ;

Murphy, William J. .

NATURE MEDICINE, 2007, 13 (03) :354-360

[3] The relevance of cytokines for development of protective immunity and rational design of vaccines [J].

Chabalgoity, Jose A. ;

Baz, Adriana ;

Rial, Analia ;

Grille, Sofia .

CYTOKINE & GROWTH FACTOR REVIEWS, 2007, 18 (1-2) :195-207

[4] The combined activation of positive costimulatory signals with modulation of a negative costimulatory signal for the enhancement of vaccine-mediated T-cell responses [J].

Chakraborty, Mala ;

Schlom, Jeffrey ;

Hodge, James W. .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2007, 56 (09) :1471-1484

[5]

Freund J, 1937, P SOC EXP BIOL MED, V37, P509

[6] Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling [J].

Gavin, Amanda L. ;

Hoebe, Kasper ;

Duong, Bao ;

Ota, Takayuki ;

Martin, Christopher ;

Beutler, Bruce ;

Nemazee, David .

SCIENCE, 2006, 314 (5807) :1936-1938

[7]

GLENNY AT, 1926, J PATHOL BACTERIOL, V29, P28

[8]

Guy B, 2007, NAT REV MICROBIOL, V5, P505, DOI 10.1038/nrmicro1681

[9]

HERBERT WJ, 1968, IMMUNOLOGY, V14, P301

[10] ANTIGENICITY OF SOLUBLE PROTEIN IN PRESENCE OF HIGH LEVELS OF ANTIBODY - A POSSIBLE MODE OF ACTION OF ANTIGEN ADJUVANTS [J].

HERBERT, WJ .

NATURE, 1966, 210 (5037) :747-&

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