Effect of Chlamydia trachomatis infection on atherosclerosis in apolipoprotein E-deficient mice

被引：20

作者：

Blessing, E

Nagano, S

Campbell, LA

Rosenfeld, ME

Kuo, CC

机构：

[1] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[2] Univ Washington, Interdisciplinary Grad Program Nutr Sci, Seattle, WA 98195 USA

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 12期

关键词：

D O I：

10.1128/IAI.68.12.7195-7197.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have previously demonstrated that Chlamydia pneumoniae accelerates plaque formation in apolipoprotein E-deficient (ApoE(-/-)) mice following intranasal inoculations. In this study, we evaluated the effect of respiratory tract infection with Chlamydia trachomatis on the progression of atherosclerosis in ApoE(-/-) mice. The study showed that in contrast to infection with Chlamydia pneumoniae, infection of the lung and aorta with C. trachomatis was mild and transient and did not significantly accelerate plaque development.

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页码：7195 / 7197

页数：3

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