One-pot multicomponent synthesis of two novel thiolactone scaffolds

被引：10

作者：

Beck, B. ^{[1
]}

Srivastava, S. ^{[1
]}

Khoury, K. ^{[1
]}

Herdtweck, E. ^{[2
]}

Doemling, Alexander ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Pharm, Pittsburgh, PA 15261 USA

[2] Tech Univ Munich, Munich, Germany

来源：

MOLECULAR DIVERSITY | 2010年 / 14卷 / 03期

关键词：

Multicomponent reaction (MCR); Isocyanide; Thiolactone; Virtual library; MORPHOLIN-2-ONE DERIVATIVES; POTENTIAL 1,3-DIPOLES; EFFICIENT SYNTHESIS; ALZHEIMERS-DISEASE; FACILE SYNTHESIS; HOMOCYSTEINE; ISOCYANIDES; ANALOGS; ACID; CYCLOADDITION;

D O I：

10.1007/s11030-010-9249-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We designed two novel thiolactone scaffolds. Both scaffolds can be accessed by a convergent Ugi multicomponent reaction (MCR) and are, thus, amenable to library synthesis. Design, stereoselectivity, structures, full experimental details, and virtual libraries will be reported.

引用

收藏

页码：479 / 491

页数：13

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