Glycosyl phenylthiosulfonates (Glyco-PTS): novel reagents for glycoprotein synthesis

被引：70

作者：

Gamblin, DP ^{[1
]}

Garnier, P ^{[1
]}

Ward, SJ ^{[1
]}

Oldham, NJ ^{[1
]}

Fairbanks, AJ ^{[1
]}

Davis, BG ^{[1
]}

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 21期

基金：

英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1039/b306990g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Controlled site-selective glycosylation can be achieved by combining site-directed cysteine mutagenesis with chemical modification of the introduced thiol; a new class of more efficient chemoselective reagents, glycosyl phenylthiosulfonates, allow rapid glycosylations of representative simple thiols, peptides and proteins.

引用

页码：3642 / 3644

页数：3

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