Changing epidemiology of human brucellosis, Germany, 1962-2005

被引:81
作者
Al Dahouk, Sascha
Neubauer, Heinrich
Hensel, Andreas
Schoeneberg, Irene
Noeckler, Karsten
Alpers, Katharina
Merzenich, Hiltrud
Stark, Klaus
Jansen, Andreas
机构
[1] Univ Aachen, Dept Internal Med 3, Rhein Westfal TH Aachen, D-52074 Aachen, Germany
[2] Friedrich Loeffler Inst, Jena, Germany
[3] Fed Inst Risk Assessment, Berlin, Germany
[4] Robert Koch Inst, D-1000 Berlin, Germany
[5] Johannes Gutenberg Univ Mainz, Mainz, Germany
关键词
D O I
10.3201/eid1312.070527
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Trends in the epidemiology of human brucellosis in Germany were investigated by analyzing national surveillance data (1962-2005) complemented by a questionnaire-based survey (1995-2000). After a steady decrease in brucellosis incidence from 1962 to the 1980s, a persistent number of cases has been reported in recent years, with the highest incidence in Turkish immigrants (0.3/100,000 Turks vs. 0.01/100,000 in the German population; incidence rate ratio 29). Among cases with reported exposure risks, 59% were related to the consumption of unpasteurized cheese from brucellosis-endemic countries. The mean diagnostic delay was 2.5 months. Case fatality rates increased from 0.4% (1978-1981) to a maximum of 6.5% (1998-2001). The epidemiology of brucellosis in Germany has evolved from an endemic occupational disease among the German population into a travel-associated foodborne zoonosis, primarily affecting Turkish immigrants. Prolonged diagnostic delays and high case fatality call for targeted public health measures.
引用
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页码:1895 / 1900
页数:6
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