Notch: Control of lymphocyte differentiation in the periphery

被引：39

作者：

Dallman, MJ ^{[1
]}

Smith, E

Benson, RA

Lamb, JR

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Biol Sci, Sect Immunol & Infect, London SW7 2AZ, England

[2] Univ Edinburgh, MRC, Ctr Inflammat Res, Immunobiol Grp, Edinburgh EH8 9YL, Midlothian, Scotland

[3] GlaxoSmithKline, Translat Med & Genet, Greenford, Middx, England

来源：

CURRENT OPINION IN IMMUNOLOGY | 2005年 / 17卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.coi.2005.04.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The complexity of the Notch signalling pathway has impeded progress in understanding its precise role in differentiation processes of the mature peripheral immune system. Nevertheless, both B and T lymphocyte responses are undoubtedly influenced by Notch ligation, and defining the mechanisms by which this is achieved remains a challenge. How the innate-adaptive interface and interactions between lymphocytes can be affected, together with the potential of this pathway for therapeutic intervention remain important and stimulating issues.

引用

页码：259 / 266

页数：8

共 45 条

[41] Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1B cells [J].