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Aging of bone marrow mesenchymal stromal/stem cells: Implications on autologous regenerative medicine

被引：40
作者：
Charif, N. [1 ,2 ]
Li, Y. Y. [1 ,2 ]
Targa, L. [1 ,2 ]
Zhang, L. [2 ,4 ]
Ye, J. S. [2 ,4 ]
Li, Y. P. [2 ,5 ]
Stoltz, J. F. [1 ,2 ,3 ]
Han, H. Z. [2 ,6 ,7 ]
de Isla, N. [1 ,2 ]
机构：
[1] CNRS UL, UMR 7365, IMoPA, Fac Med, Vandoeuvre Les Nancy, France
[2] CNRS GDRI 0851, France Chine Stem Cells & Regenerat Med, Vandoeuvre Les Nancy, France
[3] CHRU Nancy, UTCT, FR CNRS INSERM UL CHU, Vandoeuvre Les Nancy, France
[4] Calmette Hosp, Ctr Rech Biomed, Kunming, Yunnan, Peoples R China
[5] Wuhan Univ, Coll Med, Wuhan, Hubei, Peoples R China
[6] Ctr Rech Cellules Souches, Beijing, Peoples R China
[7] Ctr Rech Cellules Souches, Tianjin, Peoples R China
来源：
BIO-MEDICAL MATERIALS AND ENGINEERING | 2017年 / 28卷
关键词：
Mesenchymal stromal/stem cells; bone marrow; aging; regenerative medicine; STEM-CELLS; TELOMERASE ACTIVITY; CULTURE-CONDITIONS; LIFE-SPAN; SENESCENCE; AGE; EXPANSION; DIFFERENTIATION; REVEALS; LENGTH;
D O I：
10.3233/BME-171624
中图分类号：
R318 [生物医学工程];
学科分类号：
100103 [病原生物学];
摘要：
With their proliferation, differentiation into specific cell types, and secretion properties, mesenchymal stromal/stem cells (MSC) are very interesting tools to be used in regenerative medicine. Bone marrow (BM) was the first MSC source characterized. In the frame of autologous MSC therapy, it is important to detect donor's parameters affecting MSC potency. Age of the donors appears as one parameter that could greatly affect MSC properties. Moreover, in vitro cell expansion is needed to obtain the number of cells necessary for clinical developments. It will lead to in vitro cell aging that could modify cell properties. This review recapitulates several studies evaluating the effect of in vitro and in vivo MSC aging on cell properties.
引用
收藏
页码：S57 / S63
页数：7
相关论文
共 41 条
[1]
mTert expression correlates with telomerase activity during the differentiation of murine embryonic stem cells [J].
Armstrong, L ;
Lako, M ;
Lincoln, J ;
Cairns, PM ;
Hole, N .
MECHANISMS OF DEVELOPMENT, 2000, 97 (1-2) :109-116
[2]
Characterization of bone marrow-derived mesenchymal stem cells in aging [J].
Baker, Natasha ;
Boyette, Lisa B. ;
Tuan, Rocky S. .
BONE, 2015, 70 :37-47
[3]
Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status [J].
Basciano, Leticia ;
Nemos, Christophe ;
Foliguet, Bernard ;
de Isla, Natalia ;
de Carvalho, Marcelo ;
Nguyen Tran ;
Dalloul, Ali .
BMC CELL BIOLOGY, 2011, 12
[4]
Study of telomere length reveals rapid aging of human marrow stromal cells following in vitro expansion [J].
Baxter, MA ;
Wynn, RF ;
Jowitt, SN ;
Wraith, JE ;
Fairbairn, LJ ;
Bellantuono, I .
STEM CELLS, 2004, 22 (05) :675-682
[5]
Toward an understanding of mechanism of aging-induced oxidative stress in human mesenchymal stem cells [J].
Benameur, Laila ;
Charif, Naceur ;
Li, Yueying ;
Stoltz, Jean-Francois ;
de Isla, Natalia .
BIO-MEDICAL MATERIALS AND ENGINEERING, 2015, 25 :S41-S46
[6]
Telomere length, stem cells and aging [J].
Blasco, Maria A. .
NATURE CHEMICAL BIOLOGY, 2007, 3 (10) :640-649
[7]
Oxidative stress induces senescence in human mesenchymal stem cells [J].
Brandl, Anita ;
Meyer, Matthias ;
Bechmann, Volker ;
Nerlich, Michael ;
Angele, Peter .
EXPERIMENTAL CELL RESEARCH, 2011, 317 (11) :1541-1547
[8]
In vitro initial expansion of mesenchymal stem cells is influenced by the culture parameters used in the isolation process [J].
Chen, H. H. ;
Decot, V. ;
Ouyang, J. P. ;
Stoltz, J. F. ;
Bensoussan, D. ;
de Isla, N. G. .
BIO-MEDICAL MATERIALS AND ENGINEERING, 2009, 19 (4-5) :301-309
[9]
Replicative senescence of human bone marrow and umbilical cord derived mesenchymal stem cells and their differentiation to adipocytes and osteoblasts [J].
Cheng, HuanChen ;
Qiu, Lin ;
Ma, Jun ;
Zhang, Hao ;
Cheng, Mei ;
Li, Wei ;
Zhao, Xuefei ;
Liu, Keyu .
MOLECULAR BIOLOGY REPORTS, 2011, 38 (08) :5161-5168
[10]
Reduced Reactivation from Dormancy but Maintained Lineage Choice of Human Mesenchymal Stem Cells with Donor Age [J].
Dexheimer, Verena ;
Mueller, Sebastian ;
Braatz, Frank ;
Richter, Wiltrud .
PLOS ONE, 2011, 6 (08)
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