IL-28 and IL-29:: Newcomers to the interferon family

被引：191

作者：

Uze, Gilles ^{[1
]}

Monneron, Daniele ^{[1
]}

机构：

[1] Univ Montpellier 2, CNRS, UMR 5124, F-34095 Montpellier 5, France

来源：

BIOCHIMIE | 2007年 / 89卷 / 6-7期

关键词：

interferon; cytokine; antiviral;

D O I：

10.1016/j.biochi.2007.01.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IL-28 and IL-29 were recently described as members of a new cytokine family that shares with type I interferon (IFN) the same Jak/Stat signalling pathway driving expression of a common set of genes. Accordingly, they have been named IFN lambda. IFNs lambda exhibit several common features with type I fFNs: antiviral activity, antiproliferative activity and in vivo antiturnour activity. Importantly, however, IFNsX bind to a distinct membrane receptor, composed of IFNLR1 and IL10R2. This specific receptor usage suggests that this cytokine family does not merely replicate the type I IFN system and justifies its designation as type III IFN by the nomenclature committee of the International Society of Interferon and Cytokine Research. (C) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：729 / 734

页数：6

共 50 条

[1] Lambda interferon (IFN-λ), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo [J].

Ank, N ;

West, H ;

Bartholdy, C ;

Eriksson, K ;

Thomsen, AR ;

Paludan, SR .

JOURNAL OF VIROLOGY, 2006, 80 (09) :4501-4509

[2] IFN-λ:: Novel antiviral cytokines [J].

Ank, Nina ;

West, Hans ;

Paludan, Soren R. .

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2006, 26 (06) :373-379

[3] Role of interferons in the control of Lassa virus replication in human dendritic cells and macrophages [J].

Baize, S ;

Pannetier, D ;

Faure, C ;

Marianneau, P ;

Marendat, I ;

Georges-Courbot, MC ;

Deubel, V .

MICROBES AND INFECTION, 2006, 8 (05) :1194-1202

[4] Murine interferon lambdas (type III interferons) exhibit potent antiviral activity in vivo in a poxvirus infection model [J].

Bartlett, NW ;

Buttigieg, K ;

Kotenko, SV ;

Smith, GL .

JOURNAL OF GENERAL VIROLOGY, 2005, 86 :1589-1596

[5] The interferon-inducible RNA helicase, mda-5, is involved in measles virus-induced expression of antiviral cytokines [J].

Berghall, Heidi ;

Siren, Jukka ;

Sarkar, Devanand ;

Julkunen, Ilkka ;

Fisher, Paul B. ;

Vainionpaa, Raija ;

Matikainen, Sampsa .

MICROBES AND INFECTION, 2006, 8 (08) :2138-2144

[6] IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression [J].

Brand, S ;

Beigel, F ;

Olszak, T ;

Zitzmann, K ;

Eichhorst, ST ;

Otte, JM ;

Diebold, J ;

Diepolder, H ;

Adler, B ;

Auernhammer, CJ ;

Göke, B ;

Dambacher, J .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2005, 289 (05) :G960-G968

[7] SOCS-1 inhibits expression of the antiviral proteins 2′,5′-OAS and MxA induced by the novel interferon-λs IL-28A and IL-29 [J].

Brand, S ;

Zitzmann, K ;

Dambacher, J ;

Beigel, F ;

Olszak, T ;

Vlotides, G ;

Eichhorst, ST ;

Göke, B ;

Diepolder, H ;

Auernhammer, CJ .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 331 (02) :543-548

[8] Herpes simplex virus encephalitis in human UNC-93B deficiency [J].

Casrouge, Armanda ;

Zhang, Shen-Ying ;

Eidenschenk, Celine ;

Jouanguy, Emmanuelle ;

Puel, Anne ;

Yang, Kun ;

Alcais, Alexandre ;

Picard, Capucine ;

Mahfoufi, Nora ;

Nicolas, Nathalie ;

Lorenzo, Lazaro ;

Plancoulaine, Sabine ;

Senechal, Brigitte ;

Geissmann, Frederic ;

Tabeta, Koichi ;

Hoebe, Kasper ;

Du, Xin ;

Miller, Richard L. ;

Heron, Benedicte ;

Mignot, Cyril ;

de Villemeur, Thierry Billette ;

Lebon, Pierre ;

Dulac, Olivier ;

Rozenberg, Flore ;

Beutler, Bruce ;

Tardieu, Marc ;

Abel, Laurent ;

Casanova, Jean-Laurent .

SCIENCE, 2006, 314 (5797) :308-312

[9] Analysis of the variations in IL-28RA gene and their association with allergic rhinitis [J].

Chae, Soo-Cheon ;

Park, Young-Ran ;

Li, Chun-Shi ;

Lee, Jae-Hoon ;

Yang, Yun-Sik ;

Zhang, Qinggao ;

Kim, Kyung-Suk ;

Chung, Hun-Taeg .

EXPERIMENTAL AND MOLECULAR MEDICINE, 2006, 38 (03) :302-309

[10] Alpha and lambda interferon together mediate suppression of CD4 T cells induced by respiratory syncytial virus [J].

Chi, Bo ;

Dickensheets, Harold L. ;

Spann, Kirsten M. ;

Alston, Marc A. ;

Luongo, Cindy ;

Dumoutier, Laure ;

Huang, Jiaying ;

Renauld, Jean-Christophe ;

Kotenko, Sergei V. ;

Roederer, Mario ;

Beeler, Judy A. ;

Donnelly, Raymond P. ;

Collins, Peter L. ;

Rabin, Ronald L. .

JOURNAL OF VIROLOGY, 2006, 80 (10) :5032-5040

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