NMDA receptor subunits are phosphorylated by activation of neurotrophin receptors in PSD of rat spinal cord

被引：32

作者：

Di Luca, M

Gardoni, F

Finardi, A

Pagliardini, S

Cattabeni, F

Battaglia, G

Missale, C

机构：

[1] Univ Milan, Inst Pharmacol Sci, I-20133 Milan, Italy

[2] Univ Brescia, Dept Biomed Sci & Biotechnol, Div Pharmacol, I-25124 Brescia, Italy

[3] Neurol Inst C Besta, I-20133 Milan, Italy

来源：

NEUROREPORT | 2001年 / 12卷 / 06期

关键词：

neurotrophin receptors; NMDA; phosphorylation; postsynaptic density; spinal cord;

D O I：

10.1097/00001756-200105080-00049

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have investigated the distribution of NMDA and neurotrophin receptor systems and their reciprocal interactions in post-synaptic densities (PSD) purified from spinal cord. NMDA receptor subunits, trkA and trkB, but not trkC, were present in spinal cord PSD. The incubation of PSD with BDNF and NGF induced the phosphorylation of NR2A and B subunits. This phosphorylation was counteracted by antibodies directed against the catalytic domain of trkA and trkB receptors and by genistein. These results suggest the existence of a previously unexplored cross-talk between neurotrophins and NMDA receptors in rat spinal cord neurons. NeuroReport 12:1301-1305 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：1301 / 1305

页数：5

共 22 条

[1] Brain-derived neurotrophic factor mediates the anti-apoptotic effect of NMDA in cerebellar granule neurons: Signal transduction cascades and site of ethanol action [J].