Sulfated β-(1→4)-galacto-oligosaccharides and their effect on angiogenesis

被引：23

作者：

Käsbauer, CW ^{[1
]}

Paper, DH ^{[1
]}

Franz, G ^{[1
]}

机构：

[1] Univ Regensburg, Inst Pharmaceut Biol, D-93040 Regensburg, Germany

来源：

CARBOHYDRATE RESEARCH | 2001年 / 330卷 / 03期

关键词：

angiogenesis inhibitor; CAM-assay; FGF-2; galactan; sulfated galacto-oligosaccharides;

D O I：

10.1016/S0008-6215(00)00305-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sulfated beta-(1 --> 4)-galacto-oligosaccharides were prepared from an arabino-galacto-rhamno-galacturonan from Lupinus polyphyllus Lindl. by successive partial hydrolysis and SO3-pyridine sulfation in DMF. The resulting oligosaccharide polysulfates were analyzed by analytical GPC and the sulfate content was determined by ion chromatography. DP 5 and higher showed a pronounced antiangiogenic effect with scores of 0.9-1.2 for DP 7-9 using the CAM-assay. An interaction with the fibroblast growth factor FGF-2 was noticed for DP 4-12 depending on the degree of sulfation using the FGF-2-trypsin assay. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：427 / 430

页数：4

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